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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularization
New England Journal of Medicine, Volume 353, No. 7, Year 2005
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Description
Background: Sirolimus-eluting stents and paclitaxel-eluting stents, as compared with bare-metal stents, reduce the risk of restenosis. It is unclear whether there are differences in safety and efficacy between the two types of drug-eluting stents. Methods: We conducted a randomized, controlled, single-blind trial comparing sirolimus-eluting stents with paclitaxel-eluting stents in 1012 patients undergoing percutaneous coronary intervention. The primary end point was a composite of major adverse cardiac events (death from cardiac causes, myocardial infarction, and ischemia-driven revascularization of the target lesion) by nine months. Follow-up angiography was completed in 540 of 1012 patients (53.4 percent). Results: The two groups had similar baseline clinical and angiographic characteristics. The rate of major adverse cardiac events at nine months was 6.2 percent in the sirolimus-stent group and 10.8 percent in the paclitaxel-stent group (hazard ratio, 0.56; 95 percent confidence interval, 0.36 to 0.86; P=0.009). The difference was driven by a lower rate of target-lesion revascularization in the sirolimus-stent group than in the paclitaxel-stent group (4.8 percent vs. 8.3 percent; hazard ratio, 0.56; 95 percent confidence interval, 0.34 to 0.93; P=0.03). Rates of death from cardiac causes were 0.6 percent in the sirolimus-stent group and 1.6 percent in the paclitaxel-stent group (P=0.15); the rates of myocardial infarction were 2.8 percent and 3.5 percent, respectively (P=0.49); and the rates of angiographic restenosis were 6.6 percent and 11.7 percent, respectively (P=0.02). Conclusions: As compared with paclitaxel-eluting stents, the use of sirolimus-eluting stents results in fewer major adverse cardiac events, primarily by decreasing the rates of clinical and angiographic restenosis. Copyright © 2005 Massachusetts Medical Society.
Authors & Co-Authors
Windecker, Stephan W.
Switzerland, Bern
University Hospital Bern
Jüni, Peter
Switzerland, Bern
University Hospital Bern
Roffi, Marco
Switzerland, Zurich
Universitatsspital Zurich
Lüscher, Thomas Felix
Switzerland, Zurich
Universitatsspital Zurich
Egger, Matthias
Unknown Affiliation
Meier, Bernhard
Switzerland, Bern
University Hospital Bern
Statistics
Citations: 605
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1056/NEJMoa051175
ISSN:
00284793
Research Areas
Disability
Environmental
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study