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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Soluble c-erbB-2 fragment in serum correlates with disease stage and predicts for shortened survival in patients with early-stage and advanced breast cancer
British Journal of Cancer, Volume 70, No. 4, Year 1994
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Description
Seventy-nine patients with advanced breast cancer were tested for the presence, in serum, of a 110 kDa soluble, c-erbB-2 fragment. Thirty-nine patients were seropositive. There was no correlation between seropositivity and menopausal status, or with oestrogen status. In addition, no correlation could be found between tissue c-erbB-2 immunostaining for the external domain of the c-erbB-2 receptor and the presence of soluble c-erbB-2 in serum. The presence of serum soluble c-erbB-2, however, had a significant impact on survival of patients with advanced disease, suggesting that this test may become a useful independent prognostic indicator. © Macmillan Press Ltd., 1994.
Authors & Co-Authors
Kandl, H.
South Africa, Johannesburg
University of the Witwatersrand
Seymour, Lesley K.
South Africa, Johannesburg
University of the Witwatersrand
Bezwoda, Werner Robert
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 94
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1038/bjc.1994.387
e-ISSN:
15321827
Research Areas
Cancer