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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Failure to recognize nontuberculous mycobacteria leads to misdiagnosis of chronic pulmonary tuberculosis
PLoS ONE, Volume 7, No. 5, Article e36902, Year 2012
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Description
Background: Nontuberculous mycobacterial (NTM) infections cause morbidity worldwide. They are difficult to diagnose in resource-limited regions, and most patients receive empiric treatment for tuberculosis (TB). Our objective here is to evaluate the potential impact of NTM diseases among patients treated presumptively for tuberculosis in Mali. Methods: We re-evaluated sputum specimens among patients newly diagnosed with TB (naïve) and those previously treated for TB disease (chronic cases). Sputum microscopy, culture and Mycobacterium tuberculosis drug susceptibility testing were performed. Identification of strains was performed using molecular probes or sequencing of secA1 and/or 16S rRNA genes. Results: Of 142 patients enrolled, 61 (43%) were clinically classified as chronic cases and 17 (12%) were infected with NTM. Eleven of the 142 (8%) patients had NTM disease alone (8 M. avium, 2 M. simiae and 1 M. palustre). All these 11 were from the chronic TB group, comprising 11/61 (18%) of that group and all were identified as candidates for second line treatment. The remaining 6/17 (35.30%) NTM infected patients had coinfection with M. tuberculosis and all 6 were from the TB treatment naïve group. These 6 were candidates for the standard first line treatment regimen of TB. M. avium was identified in 11 of the 142 (8%) patients, only 3/11 (27.27%) of whom were HIV positive. Conclusions: NTM infections should be considered a cause of morbidity in TB endemic environments especially when managing chronic TB cases to limit morbidity and provide appropriate treatment. © 2012 Maiga et al.
Authors & Co-Authors
Maiga, Mamoudou
Mali, Bamako
University of Bamako
Siddiqui, Sophia
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Diallo, Souleymane M’bara
Mali, Bamako
University of Bamako
Diarra, Bassirou
Mali, Bamako
University of Bamako
Traoré, Brehima Y.
Mali, Bamako
University of Bamako
Shea, Yvonne R.
United States, Bethesda
National Institutes of Health Nih
Zelazny, Adrian M.
United States, Bethesda
National Institutes of Health Nih
Dembélé, Bindongo P.P.
Mali, Bamako
University of Bamako
Goïta, Drissa
Mali, Bamako
University of Bamako
Kassambara, Hamadoun
Mali, Bamako
University of Bamako
Hammond, Abdulrahman S.
Mali, Bamako
University of Bamako
Polis, Michael A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Tounkara, Anatole
Mali, Bamako
University of Bamako
Statistics
Citations: 110
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0036902
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Locations
Mali