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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study
European Archives of Psychiatry and Clinical Neuroscience, Volume 270, No. 6, Year 2020
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Description
The severity of psychopathology has a strong negative impact on quality of life (QoL) among older adults with schizophrenia spectrum disorder. However, because these subjects generally experience multiple psychiatric symptoms, it remains unclear whether decreased QoL in this population is due to specific symptoms (e.g., hallucinations), specific dimensions of psychopathology (e.g., negative symptoms), a general psychopathology dimension representing the shared effect across all psychiatric symptoms, or a combination of these explanations. Data were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N = 353) multicenter sample of older adults with schizophrenia spectrum disorder recruited from French public-sector psychiatric departments. We used structural equation modeling to examine the shared and specific effects of psychiatric symptoms on QoL, while adjusting for sociodemographic characteristics, general medical conditions, global cognitive functioning and psychotropic medications. Psychiatric symptoms and QoL were assessed face-to-face by psychiatrists using the Brief Psychiatric Rating Scale (BPRS) and the Quality of Life Scale (QLS). Among older adults with schizophrenia spectrum disorder, effects of psychiatric symptoms on QoL were exerted mostly through a general psychopathology dimension (β = − 0.43, p < 0.01). Negative symptom dimension had an additional negative effect on QoL beyond the effect of that factor (β = − 0.28, p < 0.01). Because psychiatric symptoms affect QoL mainly through two dimensions of psychopathology, i.e., a general psychopathology dimension and a negative symptom dimension, mechanisms underlying those dimensions should be considered as promising targets for therapeutic interventions to substantially improve quality of life of this vulnerable population. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Authors & Co-Authors
Hoertel, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
France, Paris
Université Paris Cité
Blanco, Carlos V.
Unknown Affiliation
Adès, Jean
Unknown Affiliation
Amado, Isabelle Reine
Unknown Affiliation
Dubertret, Caroline
Unknown Affiliation
Guillin, Olivier
Unknown Affiliation
Haffen, Emmanuel
Unknown Affiliation
Jalenques, Isabelle
Unknown Affiliation
Kébir, Oussama
Unknown Affiliation
Krebs, Marie Odile
Unknown Affiliation
Leboyer, Marion
Unknown Affiliation
Llorca, Pierre Michel
Unknown Affiliation
Lucas, Stephane
Unknown Affiliation
Mahi, Mohammed
Unknown Affiliation
Nubukpo, Philippe
Unknown Affiliation
Pringuey, Dominique J.
Unknown Affiliation
Sechter, Daniel
Unknown Affiliation
Verdoux, Hélène
Unknown Affiliation
Statistics
Citations: 18
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.1007/s00406-019-01026-9
ISSN:
09401334
Research Areas
Disability
Mental Health
Study Design
Cross Sectional Study
Cohort Study