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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The role of dendritic cells in the initiation of immune responses to contact sensitizers. I. In vivo exposure to antigen
Cellular Immunology, Volume 94, No. 2, Year 1985
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Description
Twenty-four hours after skin painting mice with picryl chloride (PIC) there was a four- to fivefold increase in the numbers of dendritic cells (DC) isolated from the lymph nodes. These DC initiated primary proliferative and cytotoxic responses when added to cultures of normal syngeneic lymph node cells. The proliferative response was enhanced when the donors of the responding lymph node cells were sensitized with the same antigen. Contact sensitivity developed in syngeneic mice injected into the footpads with 30,000-50,000 DC from lymph nodes of mice painted with picryl chloride 1 day previously. Thus, 1 day after skin painting mice, there were dendritic cells in the draining lymph nodes which were able both to initiate primary stimulation of lymphocytes in vitro and to sensitize recipient mice to give specific delayed hypersensitivity reactions. © 1985.
Authors & Co-Authors
Knight, Stella C.
United Kingdom, London
Mrc Clinical Research Centre
Colizzi, Vittorio C.
United Kingdom, London
Mrc Clinical Research Centre
Statistics
Citations: 138
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/0008-8749(85)90266-7
ISSN:
00088749