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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The effect of bacille Calmette-Guérin vaccine strain and route of administration on induced immune responses in vaccinated infants
Journal of Infectious Diseases, Volume 193, No. 4, Year 2006
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Description
Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy in preventing tuberculosis. Both BCG strain and route of administration have been implicated in determining efficacy; however, these variables are not considered in current clinical recommendations for vaccine choice. We evaluated antigen-specific immunity after percutaneous or intradermal administration of Japanese BCG or intradermal administration of Danish BCG. Ten weeks after vaccination of neonates, percutaneous Japanese BCG had induced significantly higher frequencies of BCG-specific interferon-7-producing CD4 + and CD8+ T cells in BCG-stimulated whole blood than did intradermal Danish BCG. Similarly, percutaneous vaccination with Japanese BCG resulted in significantly greater secretion of the T helper 1-type cytokines interferon-γ, tumor necrosis factor-α, and interleukin-2; significantly lower secretion of the T helper 2-type cytokine interleukin-4; and greater CD4+ and CD8+ T cell proliferation. Thus, BCG strain and route of neonatal vaccination confer different levels of immune activation, which may affect the efficacy of the vaccine. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Davids, Virginia
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Mansoor, Nazma
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Gamieldien, Hoyam
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Gelderbloem, Sebastian J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hawkridge, Anthony J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hussey, Greg Dudley
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hughes, Elizabeth Jane
South Africa, Cape Town
University of Cape Town
Soler, Jorge H.
United States, Newark
Public Health Research Institute
Murray, Rose Ann
United States, Newark
Public Health Research Institute
Ress, Stanley R.
South Africa, Cape Town
University of Cape Town
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Statistics
Citations: 133
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1086/499825
ISSN:
00221899
Research Areas
Cancer
Maternal And Child Health