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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of advanced squamous cell carcinoma of the skin with cisplatin, 5‐fluorouracil, and bleomycin
Cancer, Volume 66, No. 8, Year 1990
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Description
The authors treated 14 patients with advanced squamous cell carcinoma (SCC) of the skin or lip with one to four cycles of combination chemotherapy consisting of cisplatin by bolus injection, and 5‐fluorouracil (5‐FU) and bleomycin by continuous 5‐day infusion. Objective responses were seen in 11 of the 13 evaluable patients (84%). Four patients had a complete remission (30%) and seven patients, a partial remission (54%). Local control after definitive complementary radiation and/or surgical treatment was achieved in seven patients. Toxic side effects was acceptable; they consisted of nausea and vomiting in all patients, transient skin changes, hematologic (Grade 3/4) abnormalities in four patients, and pulmonary fibrosis in one elderly patient. These results show that this chemotherapy combination could play a role in reducing the tumor mass and in facilitating definitive treatment to obtain better functional and cosmetic results in advanced SCC of the skin. Copyright © 1990 American Cancer Society
Authors & Co-Authors
Sadek, Hussein
France, Villejuif
Institut de Cancerologie Gustave Roussy
Azli, Nasser
Algeria, Constantine
Centre Hospitalo-universitaire dr Benbadis Constantine
Wendling, Jean Louis
France, Villejuif
Institut de Cancerologie Gustave Roussy
Cvitkovic, Esteban
France, Villejuif
Institut de Cancerologie Gustave Roussy
Rahal, Mohammed Mahmoud
Algeria, Constantine
Centre Hospitalo-universitaire dr Benbadis Constantine
Mamelle, Gerard
France, Villejuif
Institut de Cancerologie Gustave Roussy
Guillaume, Jean Claude
France, Villejuif
Institut de Cancerologie Gustave Roussy
Armand, Jean Pierre
France, Villejuif
Institut de Cancerologie Gustave Roussy
Avril, Marie Fraņcoise
France, Villejuif
Institut de Cancerologie Gustave Roussy
Statistics
Citations: 183
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1002/1097-0142(19901015)66:8<1692::AID-CNCR2820660807>3.0.CO;2-Y
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Environmental
Health System And Policy