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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Is prehypertension an independent predictor of target organ changes in young-to-middle-aged persons of African descent?
Journal of Hypertension, Volume 26, No. 12, Year 2008
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Description
AIM: We sought to determine whether prehypertension (BP = 120-139/80-89 mmHg) is associated with target organ changes independent of confounders. METHODS: In 771 participants from a population sample of African ancestry, approximately 46% of whom had hypertension, and approximately 30% prehypertension, organ damage was assessed from echocardiography (left ventricular mass indexed to height, the mean of posterior and septal wall thickness and early-to-late transmitral velocity), 24-h urine samples (urinary albumin-to-creatinine ratio), serum creatinine concentrations, and carotid-femoral pulse wave velocity. Ambulatory blood pressure values that met with prespecified quality control criteria were available in 539 participants. RESULTS: A greater proportion of hypertensives (P < 0.0001) but not prehypertensives had elevated 24-h blood pressure values as compared with participants with optimal blood pressure values. Before adjustment for confounders, hypertension was associated with all target organ changes (P < 0.0001), and after adjustment, an independent association was noted between hypertension and all target organ changes (P < 0.05-0.005) except albumin-to-creatinine ratio or serum creatinine concentrations. Before adjustment, prehypertension was associated with left ventricular mass indexed to height, mean wall thickness, pulse wave velocity, and early-to-late transmitral velocity (P < 0.05-0.001), but not with other target organ changes. After adjustment, however, prehypertension was not independently associated with target organ changes. Other factors independently associated with target organ changes were age (all target organs), waist circumference (left ventricular mass indexed to height and early-to-late transmitral velocity) and diabetes mellitus (albumin-to-creatinine ratio and pulse wave velocity). Interactions between prehypertension and any of the alternative risk factors were not independent predictors of target organ changes. CONCLUSION: Although associated with it, prehypertension is not an independent predictor of organ damage in young-to-middle-aged persons of African ancestry. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Norton, Gavin R.
South Africa, Johannesburg
School of Physiology
Maseko, Muzi Joseph
South Africa, Johannesburg
School of Physiology
Libhaber, Elena N.
South Africa, Johannesburg
School of Physiology
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Libhaber, Carlos D.
South Africa, Johannesburg
School of Physiology
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Majane, Olebogeng H.I.
South Africa, Johannesburg
School of Physiology
Dessein, Patrick Hector M.C.
South Africa, Johannesburg
School of Physiology
Sareli, Pinhas E.
South Africa, Johannesburg
School of Physiology
Woodiwiss, Angela Jill
South Africa, Johannesburg
School of Physiology
South Africa, Johannesburg
School of Clinical Medicine
Statistics
Citations: 64
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1097/HJH.0b013e328311f296
ISSN:
02636352
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study