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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vitro release kinetics of antituberculosis drugs from nanoparticles assessed using a modified dissolution apparatus
BioMed Research International, Volume 2013, Article 136590, Year 2013
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Description
The aim of this study was to assess the in vitro release kinetics of antituberculosis drug-loaded nanoparticles (NPs) using a "modified" cylindrical apparatus fitted with a regenerated cellulose membrane attached to a standard dissolution apparatus (modifiedcylinder method). The model drugs that were used were rifampicin (RIF) and moxifloxacin hydrochloride (MX). Gelatin and polybutyl cyanoacrylate (PBCA) NPs were evaluated as the nanocarriers, respectively. The dissolution and release kinetics of the drugs from loaded NPs were studied in different media using the modified cylinder method and dialysis bag technique was used as the control technique. The results showed that use of the modified cylinder method resulted in different release profiles associated with unique release mechanisms for the nanocarrier systems investigated. The modified cylinder method also permitted discrimination between forced and normal in vitro release of the model drugs from gelatin NPs in the presence or absence of enzymatic degradation. The use of dialysis bag technique resulted in an inability to differentiate between the mechanisms of drug release from the NPs in these cases. This approach offers an effective tool to investigate in vitro release of RIF and MX from NPs, which further indicate that this technique can be used for performance testing of nanosized carrier systems. © 2013 Yuan Gao et al.
Authors & Co-Authors
Gao, Yuan
Unknown Affiliation
Zuo, Jieyu
Unknown Affiliation
Bou-Chacra, Nadia Araci
Unknown Affiliation
Pinto, Terezinha De Jesus Andreoli
Unknown Affiliation
Clas, Sophie Dorothee
Unknown Affiliation
Walker, Roderick Bryan
Unknown Affiliation
Löbenberg, Raimar
Unknown Affiliation
Statistics
Citations: 75
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1155/2013/136590
ISSN:
23146133
e-ISSN:
23146141
Research Areas
Noncommunicable Diseases