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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Willingness of Kenyan HIV-1 serodiscordant couples to use antiretroviral-based HIV-1 prevention strategies
Journal of Acquired Immune Deficiency Syndromes, Volume 61, No. 1, Year 2012
Notification
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Description
Introduction: Antiretroviral treatment (ART) and pre-exposure prophylaxis (PrEP) have demonstrated efficacy as new human immunodeficiency virus-1 (HIV-1) prevention approaches for HIV-1 serodiscordant couples. Methods: Among Kenyan HIV-1 serodiscordant heterosexual couples participating in a clinical trial of PrEP, we conducted a cross-sectional study and used descriptive statistical methods to explore couples' willingness to use antiretrovirals for HIV-1 prevention. The study was conducted before July 2011, when studies among heterosexual populations reported that ART and PrEP reduced HIV-1 risk. Results: For 181 couples in which the HIV-1-infected partner had a CD4 count 350 cells per microliter and had not yet initiated ART (and thus did not qualify for ART under Kenyan guidelines), 60.2% of HIV-1 infected partners (69.4% of men and 57.9% of women) were willing to use early ART (at CD4 350 cells per microliter) for HIV-1 prevention. Among HIV-1 uninfected partners, 92.7% (93.8% of men and 86.1% of women) reported willingness to use PrEP. When given a hypothetical choice of early ART or PrEP for HIV-1 prevention, 52.5% of HIV-1-infected participants would prefer to initiate ART early and 56.9% of HIV-1-uninfected participants would prefer to use PrEP. Conclusions: Nearly 40% of Kenyan HIV-1-infected individuals in known HIV-1 serodiscordant partnerships reported reservations about early ART initiation for HIV-1 prevention. PrEP interest in this PrEP-experienced population was high. Strategies to achieve high uptake and sustained adherence to ART and PrEP for HIV-1 prevention in HIV-1 serodiscordant couples will require responding to couples' preferences for prevention strategies. © 2012 Lippincott Williams & Wilkins.
Authors & Co-Authors
Heffron, Renee A.
United States, Seattle
University of Washington
Ngure, Kenneth K.
Kenya, Nairobi
University of Nairobi
Kenya, Nairobi
Jomo Kenyatta University of Agriculture and Technology
Mugo, Nelly Rwamba
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Kenya, Nairobi
Kenyatta National Hospital
Celum, Connie L.
United States, Seattle
University of Washington
Kurth, Ann Elizabeth
United States, Seattle
University of Washington
United States, New York
New York University
Curran, Kathryn G.
United States, Seattle
University of Washington
Baeten, Jared M.
United States, Seattle
University of Washington
Statistics
Citations: 66
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1097/QAI.0b013e31825da73f
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male
Female