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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The 3D7var5.2 (var
COMMON
) type var gene family is commonly expressed in non-placental Plasmodium falciparum malaria
Molecular and Biochemical Parasitology, Volume 127, No. 2, Year 2003
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Description
Relapse variants in chronic Plasmodium falciparum infections are antigenically distinct from the parental parasites. The variable antigen PfEMP1 expressed at the surface of the infected erythrocyte (IE) is encoded by the var gene family with ≈60 copies per haploid genome. Placental isolates commonly express DBLγ containing subtypes of var genes with homology to either 3D7var5.2 (varCOMMON) or FCR3varCSA. Here we report that varCOMMON related genes are constitutively transcribed in ≈60% of malaria infected children in Gabon. varCOMMON is conserved in field isolates over at least 2.1kb. In 3D7 parasites varCOMMON is present on chromosome 5 (var5.2) and constitutively transcribed in the opposite direction to most other var genes. It lacks a regulatory intron, an acidic terminal segment and ends in telomeric repeat sequences. varCOMMON encodes a large, hypothetical PfEMP1 of a structure similar to previous placenta-binding PfEMP1s but it is not present at the IE-surface. IE of a 3D7 clone (3D7S8) transcribe varCOMMON but express a PfEMP1 distinct from varCOMMON at the surface and adhere to placental tissues through varCOMMON independent novel mechanisms. Our report suggests that expression of varCOMMON type genes is not restricted to placental malaria. © 2003 Published by Elsevier Science B.V.
Authors & Co-Authors
Winter, Gerhard
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Solna
Public Health Agency of Sweden
Chen, Qijun
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Solna
Public Health Agency of Sweden
Flick, Kirsten
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Solna
Public Health Agency of Sweden
Canada, Winnipeg
Canadian Science Centre for Human and Animal Health
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Fernández, Victor
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Solna
Public Health Agency of Sweden
Wahlgren, Mats
Sweden, Solna
Department of Microbiology, Tumor and Cell Biology
Sweden, Solna
Public Health Agency of Sweden
Statistics
Citations: 74
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/S0166-6851(03)00004-5
ISSN:
01666851
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Gabon