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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Expression and localization of VEGF-C and VEGFR-3 in glioblastomas and haemangioblastomas
Journal of Pathology, Volume 209, No. 1, Year 2006
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Description
Primary human brain tumours account for approximately 2% of all cancers. High levels of expression of vascular endothelial growth factor-A (VEGF-A), a potent angiogenic factor, are linked to poor prognosis. In contrast, the potential role in human brain tumour biology of newer VEGF family members, VEGF-C and VEGF-D, both of which are lymphangiogenic factors, is poorly understood. In the present study, the expression of all VEGFs (VEGF-A, -B, -C, and -D) and their receptors (VEGFR-1, -2, and -3) has been assessed in 39 primary human brain tumours. The well-established findings were confirmed with VEGF-A. Surprisingly, however, VEGF-C and VEGF-D, as well as VEGFR-3, were expressed in some tumour types such as haemangioblastomas and glioblastomas, despite their lack of lymphatic vessels. VEGF-C and VEGFR-3 transcripts were localized to the tumour palisade around necrotic areas in glioblastomas and were evenly distributed throughout haemangioblastomas. VEGF-C protein was localized by immunohistochemistry to the palisade layer in glioblastomas. More than 50% of VEGF-C-positive cells also expressed the intermediate-stage inflammatory macrophage marker CD163; however, a significant proportion of VEGF-C-positive cells were CD163-negative. These data demonstrate the presence of molecules, primarily described as regulators of lymphangiogenesis, in normal human brain and brain tumours that are devoid of lymphatics. Their localization in macrophages points to a role in tumour-associated inflammation. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Authors & Co-Authors
Jenny, B.
Switzerland, Geneva
Université de Genève Faculté de Médecine
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Harrison, J. A.
Switzerland, Geneva
Université de Genève Faculté de Médecine
Baetens, Danielle
Switzerland, Geneva
Université de Genève Faculté de Médecine
Tille, J. C.
Switzerland, Geneva
Université de Genève Faculté de Médecine
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Burkhardt, K.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Mottaz, H.
Switzerland, Geneva
Université de Genève Faculté de Médecine
Kiss, J. Z.
Switzerland, Geneva
Université de Genève Faculté de Médecine
Dietrich, P. Y.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
De Tribolet, N.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Pizzolato, G. P.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Pepper, Michael S.
Switzerland, Geneva
Université de Genève Faculté de Médecine
South Africa, Centurion
Netcare Unitas Hospital
South Africa, Pretoria
Faculty of Health Sciences
Statistics
Citations: 85
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1002/path.1943
ISSN:
00223417
e-ISSN:
10969896
Research Areas
Cancer