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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei
Journal of Natural Products, Volume 69, No. 3, Year 2006
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Description
A new biflavanoid, ent-naringeninyl-(I-3α,II-8)-4′-O-methylnaringenin (6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy. This compound showed moderate activity against P. falciparum (IC50 6.7 μM). Antitrypanosomal activity (IC50 0.87 μM) was observed for 1,4,5-trihydroxy-3-(3-methylbut-2-enyl)-9H-xanthen-9-one (3). The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC50 2.0 μM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC50 52.3 μM). © 2006 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Mbwambo, Zakaria H.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Kapingu, Modest C.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Moshi, Mainen Julius
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Machumi, Francis
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Apers, Sandra
Belgium, Antwerpen
Universiteit Antwerpen
Cos, Paul G.F.
Belgium, Antwerpen
Universiteit Antwerpen
Ferreira, Daneel
United States, University
University of Mississippi
Marais, Jannie P.J.
United States, University
University of Mississippi School of Pharmacy
Vanden Berghe, Dirk A.R.S.R.
Belgium, Antwerpen
Universiteit Antwerpen
Maes, Louis J.R.M.
Belgium, Antwerpen
Universiteit Antwerpen
Vlietinck, Arnold J.
Belgium, Antwerpen
Universiteit Antwerpen
Pieters, Luc A.C.
Belgium, Antwerpen
Universiteit Antwerpen
Statistics
Citations: 101
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1021/np050406v
ISSN:
01633864
Study Locations
Tanzania