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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Far less frequent mutations in ras genes than in the p53 gene in skin tumors of xeroderma pigmentosum patients
Molecular Carcinogenesis, Volume 11, No. 2, Year 1994
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Description
Mutations in Ha‐ras, and n‐rasNras genes in squamous and basal cell carcinomas in patients with xeroderma Pigmentosum (XP) were examined by the polymerase chain reaction followed by single‐strand conformation polymorphism analysis and direct base sequencing. No mutation was detected in codons 12, 13, and 61 of the ras genes in XP skin tumors. This was in contrast with previous findings of a high frequency of mutation in the p53 gene in skin tumors in XP patients. A novel mutation in codon 6 of the ki‐ras gene was detected in a squamous cell carcinoma. The mutation was a C→T transtion at a dipyrimidine (5′‐CT) sequence and could have been produced by solar ultraviolet light. The mutated ras gene did not have the ability to transform NIH/3T3 cells. In three tumors, multiple base substitutions were detected in exon 1 of the Ki‐ras and N‐ras genes. These results and our previous work on p53 gene mutations suggest that mutations in ras genes are far less frequent than in the p53 gene in the skin tumors in XP patients and that ras genes are less important in skin tumorigenesis in XP patients that is the p53 gene. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Sato, Mayumi
Japan, Kyoto
Kyoto University
Nishigori, Chikako
Japan, Kyoto
Kyoto University
Lu, Yanjun
Japan, Kyoto
Kyoto University
Zghal, Mohammed
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Yagi, Takashi
Japan, Kyoto
Kyoto University
Takebe, Hiraku
Japan, Kyoto
Kyoto University
Statistics
Citations: 24
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1002/mc.2940110207
ISSN:
08991987
e-ISSN:
10982744
Research Areas
Cancer
Genetics And Genomics