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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endovascular and surgical treatment of unruptured MCA aneurysms: Meta-analysis and Review of the Literature
Stroke Research and Treatment, Article 348147, Year 2014
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Description
Introduction. The best treatment for unruptured middle cerebral artery (MCA) aneurysms is unclear. We perform a meta-analysis of recent publications to evaluate the results of unruptured MCA aneurysms treated with surgical clipping and endovascular coiling. Methods. A PubMed search for articles published between January 2004 and November 2013 was performed. The R statistical software package was used to create a random effects model for each desired incidence rate. Cochran's Q test was used to evaluate possible heterogeneity among the rates observed in each study. Results. A total of 1891 unruptured MCA aneurysms, 1052 clipped and 839 coiled, were included for analysis. The complete occlusion rate at 6-9 months mean follow-up was 95.5% in the clipped group and 67.8% in the coiled group (P < 0.05). The periprocedural thromboembolism rate in the clipping group was 1.8% compared with 10.7% in the aneurysms treated by coiling (P < 0.05). The recanalization rate was 0% for clipping and 14.3% for coiling (P = 0.05). Modified Rankin scores of 0-2 were obtained in 98.9% of clipped patients compared to 95.5% of coiled (NS). Conclusions. This review weakly supports clipping as the preferred treatment of unruptured MCA aneurysms. Clinical outcomes did not differ significantly between the two groups. © 2014 Spiros L. Blackburn et al.
Authors & Co-Authors
Blackburn, Spiros L.
United States, Gainesville
University of Florida
Abdelazim, Abdelrahman M.
United States, Gainesville
University of Florida
Egypt, Asyut
Assiut University
Cutler, Andrew B.
United States, Gainesville
University of Florida
Brookins, Kevin T.
United States, Gainesville
University of Florida
Fargen, Kyle Michael
United States, Gainesville
University of Florida
Hoh, Brian Lim
United States, Gainesville
University of Florida
Kadkhodayan, Yasha
United States, Minneapolis
Abbott Northwestern Hospital
Statistics
Citations: 42
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1155/2014/348147
e-ISSN:
20420056
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study
Study Approach
Systematic review