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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of hepatocellular carcinoma with adriamycin. Preliminary communication
Cancer, Volume 36, No. 4, Year 1975
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Description
In a Phase II clinical trial, 14 patients with histologically proven primary hepatocellular carcinoma were treated with adriamycin administered intravenously at a dose of 75 mg/m2 every 3 weeks. All 11 evaluable patients responded with 3 exhibiting complete tumor regression after two, three, and five courses of adriamycin respectively. The remission durations for these 3 were 3, 6, and 7 months, and their survivals were 8, 9, and 13 months, respectively. The median survival of the evaluable patients is 8 months (range 1–13 months). The side effects encountered included myelosuppression, anorexia, nausea, vomiting, and alopecia. Adriamycin seems to be an effective agent in hepatocellular carcinoma. Further trials are underway to test its true efficacy both singly and in combination with other drugs in the management of this tumor. Copyright © 1975 American Cancer Society
Authors & Co-Authors
Olweny, Charles L.M.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Princeton
Princeton Psychological Laboratory
Toya, Tom
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Princeton
Princeton Psychological Laboratory
Katongole-Mbidde, Edward
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Princeton
Princeton Psychological Laboratory
Mugerwa, Joshua W.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Princeton
Princeton Psychological Laboratory
Kyalwazi, Sebastian K.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Princeton
Princeton Psychological Laboratory
Cohen, Herman
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Princeton
Princeton Psychological Laboratory
Statistics
Citations: 162
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1002/1097-0142(197510)36:4<1250::AID-CNCR2820360410>3.0.CO;2-X
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer