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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Bladder cancer: Diagnosis with diffusion-weighted MR imaging in patients with gross hematuria
Radiology, Volume 251, No. 2, Year 2009
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Description
Purpose: To prospectively evaluate the usefulness of diffusion-weighted (DW) magnetic resonance (MR) imaging for the detection of bladder neoplasms in patients with gross hematuria of lower urinary tract origin. Materials and Methods: The study protocol received institutional ethical committee approval, and informed consent was obtained. Between April 2007 and March 2008, 130 consecutive patients with gross hematuria whose upper urinary tract had a normal appearance at ultrasonographic examination were prospectively enrolled. Mean age was 59.4 years (range, 45-75 years). All patients were evaluated by using T2-weighted high-spatial-resolution MR imaging of the urinary bladder, followed by DW MR imaging. Two radiologists independently interpreted the T2-weighted and DW images, and discrepancies were resolved by consensus. Agreement was evaluated by using the κ statistic. All patients underwent conventional cystoscopy. With cystoscopy and the final histopathologic findings as the reference standards, a comparison with imaging findings was performed by using the McNemar test. Results: The consensus diagnostic performance of DW MR imaging for identification of bladder tumors was: sensitivity, 98.1% (104 of 106); specificity, 92.3% (24 of 26); PPV, 100% (104 of 104); negative predictive value, 92.3% (24 of 26); and accuracy, 97.0% (128 of 132). Two cases were falsely negative on T2-weighted MR images but were correctly diagnosed by using DW MR images. The agreement between DW MR imaging results and cystoscopic findings was excellent (κ = 0.94) for identification of bladder neoplasm. DW MR imaging had a sensitivity and PPV of 98.5% (128 of 130) and 100% (128 of 128), respectively, for determining the cause of hematuria. Conclusion: DW MR imaging is a highly reliable imaging approach for identification of bladder tumors in patients with gross hematuria. © RSNA, 2009.
Authors & Co-Authors
Abou El-Ghar, Mohamed Abou
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
El-Assmy, Ahmed M.
Egypt, Mansoura
Faculty of Medicine
Refaie, Huda Fathy
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
El-Diasty, Tarek Abdelmoneim
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Statistics
Citations: 118
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1148/radiol.2503080723
ISSN:
00338419
e-ISSN:
15271315
Research Areas
Cancer