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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Use of whole-genome sequencing in the investigation of a nosocomial influenza virus outbreak
Journal of Infectious Diseases, Volume 218, No. 9, Year 2018
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Description
Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
Authors & Co-Authors
Houlihan, Catherine F.
Unknown Affiliation
Frampton, Dan
Unknown Affiliation
Ferns, Ruth Bridget
United Kingdom, Oxford
Nihr Oxford Health Biomedical Research Centre
Grant, Paul R.
Unknown Affiliation
Hail, Leila
Unknown Affiliation
Mattes, Frank M.
Unknown Affiliation
Kozlakidis, Zisis
Unknown Affiliation
Morris, Lynn G.
Unknown Affiliation
Hayward, Andrew C.
Unknown Affiliation
Nastouli, Eleni
United Kingdom, London
University College London
Statistics
Citations: 43
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jiy335
ISSN:
00221899
Research Areas
Cancer
Health System And Policy