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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Worldwide genetic variation at the 3′ untranslated region of the HLA-G gene: Balancing selection influencing genetic diversity
Genes and Immunity, Volume 15, No. 2, Year 2014
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Description
The HLA-G (human leukocyte antigen-G) molecule plays a pivotal role in immune tolerance by inhibiting different cell subsets involved in both innate and adaptive immunity. Besides its primary function in maintaining the maternal-fetal tolerance, HLA-G has been involved in a wide range of pathological conditions where it can be either favorable or detrimental to the patient, depending on the nature of the pathology. Although several studies have demonstrated the utmost importance of the 3′ untranslated region (3′UTR) in the HLA-G expression profile, limited data exist on the sequence variability of this gene region in human populations. In this study, we characterized the genetic diversity and haplotype structure of the HLA-G 3′UTR by resequencing 444 individuals from three sub-Saharan African populations and retrieving data from the 1000 Genomes project and the literature. A total of 1936 individuals representing 21 worldwide populations were combined and jointly analyzed. Our data revealed a high level of nucleotide diversity, an excess of intermediate frequency variants and an extremely low population differentiation, strongly supporting a history of balancing selection at this locus. The 14-bp insertion/deletion polymorphism was further pointed out as the likely target of selection, emphasizing its potential role in the post-transcriptional regulation of HLA-G expression. © 2014 Macmillan Publishers Limited.
Authors & Co-Authors
Sabbagh, Audrey
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Luisi, Pierre
Spain, Barcelona
Parc de Recerca Biomèdica de Barcelona
Castelli, Erick C.
Brazil, Sao Paulo
Universidade Estadual Paulista Júlio de Mesquita Filho
Gineau, Laure
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Courtin, David
Benin, Cotonou
University of Abomey-calavi
Milet, Jacqueline
Benin, Cotonou
University of Abomey-calavi
Massaro, Juliana Doblas
Brazil, Sao Paulo
Universidade de São Paulo
Laayouni, Hafid
Spain, Barcelona
Parc de Recerca Biomèdica de Barcelona
Moreau, Philippe J.
France, Paris
Hôpital Saint-louis
France, Paris
Institut de Recherche Saint-louis
Donadi, E.
Brazil, Sao Paulo
Universidade de São Paulo
Garcia, André
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Statistics
Citations: 72
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1038/gene.2013.67
ISSN:
14664879
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study