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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Adverse event reporting and developments in radiation biology after normal tissue injury: International Atomic Energy Agency consultation
International Journal of Radiation Oncology Biology Physics, Volume 64, No. 5, Year 2006
Notification
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Description
Purpose: Recent research has enhanced our understanding of radiation injury at the molecular-cellular and tissue levels; significant strides have occurred in standardization of adverse event reporting in clinical trials. In response, the International Atomic Energy Agency, through its Division of Human Health and its section for Applied Radiation Biology and Radiotherapy, organized a consultation meeting in Atlanta (October 2, 2004) to discuss developments in radiobiology, normal tissue reactions, and adverse event reporting. Methods and Materials: Representatives from cooperative groups of African Radiation Oncology Group, Curriculo Radioterapeutica Ibero Latino Americana, European Organization for Research and Treatment of Cancer, National Cancer Institute of Canada Clinical Trials Group, Radiation Therapy Oncology Group, and Trans-Tasman Radiation Oncology Group held the meeting discussion. Results: Representatives of major radiotherapy groups/organizations and prominent leaders in radiotherapy discussed current understanding of normal tissue radiobiologic effects, the design and implementation of future clinical and translational projects for normal tissue injury, and the standardization of adverse-event reporting worldwide. Conclusions: The consensus was to adopt NCI comprehensive adverse event reporting terminology and grading system (CTCAE v3.0) as the new standard for all cooperative group trials. Future plans included the implementation of coordinated research projects focusing on normal tissue biomarkers and data collection methods. © 2006 Elsevier Inc.
Authors & Co-Authors
Chen, Yuhchyau C.
United States, Rochester
University of Rochester School of Medicine and Dentistry
United States, Rochester
University of Rochester Medical Center
Trotti, Andy M.
United States, Tampa
Moffitt Cancer Center
Coleman, C. Norman
United States, Rockville
National Cancer Institute Nci
MacHtay, Mitchell X.
United States, Philadelphia
Thomas Jefferson University Hospital
United States, Salt Lake City
Radiation Therapy Oncology Group
Mirimanoff, Renè Olivier
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Hay, John H.
Canada, Vancouver
British Columbia Cancer Agency
Canada, Kingston
Canadian Cancer Trials Group
O'Brien, Peter C.
Australia, Waratah
Newcastle Mater Misericordiae Hospital
Australia, Newcastle
Trans-tasman Radiation Oncology Group
Elgueddari, Brahim El Khalil
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
South Africa, Cape Town
African Radiation Oncology Group
Salvajoli, João Víctor
Brazil, Sao Paulo
A.c.camargo Cancer Center
Peru, Lima
Curriculo Radioterapeutica Ibero Latino Americana
Jeremić, Branislav M.
Austria, Vienna
International Atomic Energy Agency, Vienna
Statistics
Citations: 25
Authors: 10
Affiliations: 17
Identifiers
Doi:
10.1016/j.ijrobp.2005.10.014
ISSN:
03603016
Research Areas
Cancer
Violence And Injury
Study Design
Grounded Theory