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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Anti-inflammatory coumarin and benzocoumarin derivatives from Murraya alata
Journal of Natural Products, Volume 78, No. 2, Year 2015
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Description
Two new rare 8-methylbenzo[h]coumarins, muralatins A and B (1, 2), nine new C-8-substituted coumarins, muralatins C-K (3-11), and 22 known analogues (12-33) were isolated from the leaves of Murraya alata. The absolute configurations of compounds 5, 11, 23, 24, 27, 30, and 33 were assigned via comparison of their specific rotations, by Moshers method, and by single-crystal X-ray diffraction and electronic circular dichroism (ECD) data of the in situ formed transition metal complexes. A putative biosynthesis pathway to 1 and 2 is proposed, and the chemical synthesis of 1 was accomplished through electrocyclization of 5,7-dimethoxy-8-[(Z)-3-methylbut-1,3-dienyl)]coumarin (12). Compounds 1, 2, 8, 12, and 31 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values of 6.0-14.5 μM. © 2015 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Ferreira, Daneel
United States, University
University of Mississippi School of Pharmacy
Zjawiony, Jordan
United States, University
University of Mississippi School of Pharmacy
Tu, Pengfei
China, Beijing
Peking University
Statistics
Citations: 91
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1021/np500861u
ISSN:
01633864