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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis)
Microbes and Infection, Volume 4, No. 13, Year 2002
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Description
Different mechanisms underlie the phenomenon of peripheral tolerance. Recently, a new subset of CD4+ T cells, called T regulatory-1 (Tr1) cells, was described which show suppressor functions in vitro and in vivo and are characterized by a predominant production of IL-10 and/or TGF-β. Tr1 cells have so far been generated experimentally in an IL-10-rich environment and hold promise for exploitation in the suppression of alloreactions and inflammatory or allergic dispositions. However, these cells have not been characterized in infectious diseases. Here we show that in the chronic helminth infection onchocerciasis (river blindness), where patients have relatively little sign of dermatitis despite the presence of millions of small worms in the skin, T cells can be obtained which bear characteristics of Tr1 cells, producing no IL-2 or IL-4 but substantial amounts of IL-10, variable amounts of IL-5, and some IFN-γ. These cells display elevated amounts of CTLA-4 after stimulation and are able to inhibit other T cells in coculture, in contrast to Th1 and Th2 clones. This is the first time that this type of suppressor T cell has been cloned as naturally occurring during an infectious disease. © 2002 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Authors & Co-Authors
Satoguina, Judith S.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Mempel, Martin
France, Paris
Institut Pasteur, Paris
Larbi, John Asiedu
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Badusche, Marlis
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Löliger, Cornelius C.
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Adjei, Ohene
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Gachelin, Gabriel
France, Paris
Institut Pasteur, Paris
Fleischer, Bernhard
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Hoerauf, Achim M.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Statistics
Citations: 239
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/S1286-4579(02)00014-X
ISSN:
12864579
Research Areas
Infectious Diseases