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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Circulating biomarkers of immune activation distinguish viral suppression from nonsuppression in HAART-treated patients with advanced HIV-1 subtype C infection
Mediators of Inflammation, Volume 2014, Article 198413, Year 2014
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Description
Few studies have examined immune activation profiles in patients with advanced HIV-1 subtype C infection or assessed their potential to predict responsiveness to HAART. BioPlex, ELISA, and nephelometric procedures were used to measure plasma levels of inflammatory biomarkers in HIV-1 subtype C-infected patients sampled before and after 6 months of successful HAART (n=20); in patients failing HAART (n=30); and in uninfected controls (n=8). Prior to HAART, CXCL9, CXCL10, β2M, sTNF-R1, TGF-β1, IFN-γ, IL-6, TNF, and sCD14 were significantly elevated in HIV-1-infected patients compared to controls (P<0.01). All of these markers, with the exception of sTNF-R1, were also elevated in patients failing HAART (P<0.05). The persistently elevated levels of CXCL9, CXCL10, and β2M in patients failing therapy in the setting of a marked reduction in these markers in patients on successful HAART suggest that they may be useful not only to monitor immune activation during HAART, but also to distinguish between good and poor responders. In the case of sCD14 and TGF-β1, the levels of these biomarkers remained persistently elevated despite HAART-induced virological suppression, a finding that is consistent with ongoing monocyte-macrophage activation, underscoring a potential role for adjuvant anti-inflammatory therapy. © 2014 Glen Malherbe et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3997875/bin/198413.f1.pdf
Authors & Co-Authors
Malherbe, Glen P.
South Africa, Pretoria
Faculty of Health Sciences
Steel, Helen C.
South Africa, Pretoria
Faculty of Health Sciences
Cassol, Sharon A.
South Africa, Pretoria
Faculty of Health Sciences
De Oliveira, Tulio
South Africa, Durban
Africa Health Research Institute
Seebregts, Christopher John
South Africa, Cape Town
Jembi Health Systems
South Africa, Durban
University of Kwazulu-natal
Anderson, Ronald
South Africa, Pretoria
Faculty of Health Sciences
Cassol, Edana
United States, Boston
Dana-farber Cancer Institute
Rossouw, Theresa Marié
South Africa, Pretoria
Faculty of Health Sciences
Statistics
Citations: 36
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1155/2014/198413
ISSN:
09629351
e-ISSN:
14661861
Research Areas
Infectious Diseases