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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of Helicobacter pylori eradication on ulcer recurrence after simple closure of perforated duodenal ulcer
International Journal of Surgery, Volume 7, No. 2, Year 2009
Notification
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Description
Background: This study was conducted to elucidate the prevalence of Helicobacter pylori in patients with a perforated duodenal ulcer and to determine whether eradication of H. pylori prevent ulcer recurrence following simple repair of the perforation. Patients and method: Eighty-three patients with perforated duodenal ulcer (68 males); mean age was 47.8 years ± 7.2. Antral mucosal biopsies (to determine the status of HP by rapid urease test, culture and histological examination/staining) were obtained during laparotomy by passing a biopsy forceps through the perforation site. H. pylori positive patients who had undergone patch repair were randomized into the eradication group who received amoxicillin, metranidazole plus omperazole and the control group was given omeprazole alone. Follow-up endoscopy and antral biopsies were performed at 8 weeks, 16 weeks and 1 year to show ulcer healing and determine H. pylori state. Results: Of 77 patients in the study, 65 patients (84.8%) had H. pylori. These patients were randomly divided into the triple therapy group (34 patients) and the control group (31 patients). Eradication of H. pylori was significantly higher in the triple therapy group than the control group and initial ulcer healing was significantly better in the eradication group. After 1 year, ulcer recurrence was (6.1%) in the eradication group vs. (29.6%) in the control group (P = 0.001). Conclusion: H. pylori was present in a high proportion of patients with duodenal ulcer perforation. Eradication of H. pylori after simple closure of a perforated duodenal ulcer reduced the incidence of recurrent ulcer. © 2008 Surgical Associates Ltd.
Authors & Co-Authors
El Nakeeb, Ayman M.
Egypt, Mansoura
Faculty of Medicine
Fikry, Amir
Egypt, Mansoura
Faculty of Medicine
Abd El-Hamed, Tito M.
Egypt, Mansoura
Faculty of Medicine
Fouda, El Yamani
Egypt, Mansoura
Faculty of Medicine
El-Awady, Saleh Ibrahim
Egypt, Mansoura
Faculty of Medicine
Youssef, Tamer Fady
Egypt, Mansoura
Faculty of Medicine
Sherief, Doaa M.
Egypt, Mansoura
Faculty of Medicine
Farid, Mohamed E.
Egypt, Mansoura
Faculty of Medicine
Statistics
Citations: 37
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.ijsu.2008.12.001
ISSN:
17439191
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study