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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increases in human papillomavirus detection during early HIV infection among women in Zimbabwe
Journal of Infectious Diseases, Volume 203, No. 8, Year 2011
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Description
Background. Individuals who acquire human immunodeficiency virus (HIV) may experience an immediate disruption of genital tract immunity, altering the ability to mount a local and effective immune response. This study examined the impact of early HIV infection on new detection of human papillomavirus (HPV). Methods. One hundred fifty-five Zimbabwean women with observation periods before and after HIV acquisition and 486 HIV-uninfected women were selected from a cohort study evaluating hormonal contraceptive use and risk of HIV acquisition. Study visits occurred at 3-month intervals. Cervical swab samples available from up to 6 months before, at, and up to 6 months after the visit when HIV was first detected were typed for 37 HPV genotypes or subtypes. Results. We observed ∼5-fold higher odds of multiple (≥2) new HPV detections only after HIV acquisition, relative to HIV-negative women after adjusting for sexual behavior and concurrent genital tract infections. We also observed ∼2.5-fold higher odds of single new HPV detections at visits before and after HIV acquisition, relative to HIV-uninfected women in multivariable models. Conclusions. These findings suggest that HIV infection has an immediate impact on genital tract immunity, as evidenced by the high risk of multiple new HPV detections immediately after HIV acquisition. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Nowak, Rebecca G.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gravitt, Patti E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Morrison, Charles S.
United States, Durham
Fhi 360
Gange, Stephen J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kwok, Cynthia
United States, Durham
Fhi 360
Oliver, Amy E.
United States, Baltimore
Johns Hopkins University
Howard, Roslyn
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
van der Pol, Barbara J.
United States, Bloomington
Indiana University Bloomington
Salata, Robert A.
United States, Cleveland
Case Western Reserve University
Padian, Nancy S.
United States, Berkeley
University of California, Berkeley
Chipato, Tsungai
Zimbabwe, Harare
University of Zimbabwe
Munjoma, Marshall Wesley
Zimbabwe, Harare
University of Zimbabwe
Celentano, David D.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 56
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jiq172
ISSN:
00221899
Research Areas
Cancer
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Zimbabwe
Participants Gender
Female