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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum
Nature, Volume 334, No. 6179, Year 1988
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Description
Malaria is initiated by the inoculation of a susceptible host with sporozoites from an infected mosquito. The sporozoites enter hepatocytes and develop for a period as exoerythrocyte or hepatic stage parasites1. Vaccination with irradiated sporozoites can provide protective immunity1 and a recent study2 shows that this can also be conferred by immunization with a recombinant salmonella expressing only the circumsporozoite protein that normally covers the sporozoites. Protection against infection is likely to be mediated by cytotoxic CD8+ cells, as depletion of CD8+ T cells in a sporozoite-immunized animal can completely abrogate immunity3,4. Here we demonstrate directly the existence of CD8+ cytotoxic T lymphocytes (CTL) that recognize the circumsporozoite protein. B10.BR mice immunized with sporozoites or with recombinant vaccinia virus expressing the CS protein of Plasmodium falciparum contain CTL that specifically kill L cell fibroblasts transfected with the gene encoding the same CS protein. The peptide epitope from the CS protein that is recognized by CTL from this strain of mice is from a variant region of the protein. © 1988 Nature Publishing Group.
Authors & Co-Authors
Kumar, Sanjaï
United States, Bethesda
National Institutes of Health Nih
Miller, Louis H.
United States, Bethesda
National Institutes of Health Nih
Quakyi, Isabella Akyinbah
United States, Bethesda
National Institutes of Health Nih
Keister, David B.
United States, Bethesda
National Institutes of Health Nih
Houghten, Richard A.
United States, San Diego
Scripps Research Institute
Maloy, Walter Lee
United States, Bethesda
National Institutes of Health Nih
Moss, Bernard
United States, Bethesda
National Institutes of Health Nih
Berzofsky, Jay A.
United States, Bethesda
National Institutes of Health Nih
Good, Michael F.
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 167
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1038/334258a0
ISSN:
00280836
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health