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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Differential expression of Toll-like receptors in chronic hyperplastic candidosis
Oral Microbiology and Immunology, Volume 23, No. 4, Year 2008
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Description
Introduction: The first step in the host defense against oral candidosis is the recognition of Candida albicans through a set of germ-encoded pathogen recognition receptors, e.g. Toll-like receptors (TLRs). In man, 10 types of such receptors have been identified so far, of which only TLR2, TLR4, and TLR6 have been linked to mediating candidal ligands, e.g. zymosan. Methods: Biopsies from patients with chronic hyperplastic candidosis (n = 5), leukoplakia (n = 5), and healthy mucosa (n = 5) were immunohistochemically stained with antibodies to the TLRs (TLR1 to TLR9) to distinguish and compare the staining patterns of the epithelial layer in the three categories of tissues. Results: On analysis, the epithelium of all tissues was divided into three layers: basal, middle, and superficial. Two of the five chronic hyperplastic candidosis sections showed high numbers of hyphae compared to yeasts, which paralleled a decrease in the expression of TLR2 and an increase in the staining intensity of TLR4. Leukoplakia and healthy tissue sections demonstrated stronger immunostaining of TLRs, except TLR9 which showed weaker staining in some sections of the former, and in the basal layers of some sections of the latter. Discussion: This study supports the concept of negative regulation of TLRs that are either ligand-bound (e.g. in chronic hyperplastic candidosis), or not stimulated (in healthy tissue). It also augments the opinion that C. albicans, through its hyphae rather than blastospore, may utilize TLRs, i.e. TLR2, to evade the immune system of the host. Leukoplakia seems to be more immunologically alert, which reduces the chances of worsening the already-diseased tissue. © 2008 The Authors.
Authors & Co-Authors
Ali, Ahmed Salem
Finland, Helsinki
Biomedicum Helsinki
Finland, Helsinki
Helsingin Yliopisto
Libya, Benghazi
Al Arab Medical University
Natah, S.
Canada, Calgary
University of Calgary
Konttinen, Y.
Finland, Helsinki
Helsinki University Hospital
Finland, Helsinki
Orthopaedic Hospital of the Invalid Foundation
Finland, Tampere
Tekonivelsairaala Coxa oy
Statistics
Citations: 18
Authors: 3
Affiliations: 7
Identifiers
Doi:
10.1111/j.1399-302X.2007.00428.x
ISSN:
09020055
e-ISSN:
1399302X
Research Areas
Health System And Policy