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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genetic variability of human immunodeficiency virus-1 in Bahia State, Northeast, Brazil: High diversity of HIV genotypes
Journal of Medical Virology, Volume 81, No. 3, Year 2009
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Description
The HIV-1 genetic variability in Bahia state, Brazil, was investigated. DNA samples from 229 and 213 HIV-1-infected individuals were analyzed using the heteroduplex mobility assay (HMA) in gag and env fragments, respectively. One hundred seventy-five samples were characterized in both genes. Thirty-two subtype F and BF recombinant viruses were sequenced and analyzed by phylogenetic methods. The combination of HMA and sequencing results showed that seven different HIV-1 genotypes comprised this sample: 147 (84%) B/B, 4 (2.3%) F/F, 3 (1.7%) B/F, 1 (0.6%) F/B, 1 (0.6%) F/D, 1 (0.6%) BF/F, and 18 (10.3%) BF/B. A significant divergence was observed between these two techniques results (84.4%). This is explained by the low accuracy of the HMA for detecting recombinant viruses. These recombinants were unrelated to CRF12, while two sequences were related to CRF28 and CRF29. Nineteen BF mosaics shared the same gag breakpoint. In conclusion, the use of HMA may be inappropriate in regions where different subtypes are co-circulating. Subtype B is the most common genotype, however, an increased prevalence (13.1%) of different BF variants and a potentially new CRF suggest that recombination is occurring frequently in Bahia. These viruses were associated with women infected heterosexually. Finally, this study identified the presence of an F/D recombinant HIV-1 in Brazil. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Monteiro, Joana Paixão
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Junior Alcantara, Luiz Carlos
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
De Oliveira, Tulio
South Africa, Cape Town
South African College
Oliveira, Antonio Marcos
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Melo, Marco Antônio Gomes
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
Brites, Carlos R.
Brazil, Salvador
Universidade Federal da Bahia
Galvão-Castro, Bernardo
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
Statistics
Citations: 28
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.21414
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Participants Gender
Female