Cd4⁺cd25^hifoxp3⁺ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4⁺TBet⁺and CD4⁺RORγt⁺ T cells

Background: Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers. Moreover children from filaria infected mothers have been shown to be less responsive to vaccination as a consequence of an impairment of their immune response. However, it is not well known how in utero exposure to parasite antigens affects cellular immune responses.