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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of diosmectite (Smecta)® in the treatment of acute watery diarrhoea in adults: A multicentre, randomized, double-blind, placebo-controlled, parallel group study
Gastroenterology Research and Practice, Article 783196, Year 2011
Notification
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Description
Background. Although diosmectite has demonstrated efficacy in the treatment of acute watery diarrhoea in children, its efficacy in adults still needs to be assessed. The objective of this study was therefore to assess the efficacy of diosmectite on the time to recovery in adults with acute diarrhoea. Methods. A total of 346 adults with at least three watery stools per day over a period of less than 48 hours were prospectively randomized to diosmectite (6g tid) or placebo during four days. The primary endpoint was time to diarrhoea recovery. Results. In the intention-to-treat population, median time to recovery was 53.8 hours (range [3.7-167.3]) with diosmectite (n=166) versus 69.0 hours [2.2-165.2] with placebo, (n=163; P=.029), which corresponds to a difference of 15.2 hours. Diosmectite was well tolerated. Conclusion. Diosmectite at 6g tid was well tolerated and reduced the time to recovery of acute watery diarrhoea episode in a clinically relevant manner. Copyright © 2011 Faouzi Khediri et al.
Authors & Co-Authors
Cortot, A.
France, Lille
Université de Lille
France, Lille
Chu Lille
Khédiri, Faouzi
Unknown Affiliation
Mrad, Abdennebi Ilhem
Tunisia, Sfa
Regional Hospital
Azzouz, Moussadek
Tunisia
Tahar Mamouri Regional Hospital
Doughi, Hedi
Tunisia, Tunis
Interior Security Hospital
Najjar, Taoufik
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Mathiex-Fortunet, Hélène
France, Boulogne-billancourt
Ipsen
Garnier, Philippe
France, Boulogne-billancourt
Ipsen
Statistics
Citations: 29
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1155/2011/783196
ISSN:
16876121
e-ISSN:
1687630X
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study