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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Seroepidemiology of toxoplasmosis in pregnant women and detection of infection acquired during pregnancy in Cotonou, Benin
Parasite, Volume 30, Article 43, Year 2023
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Description
Assessing the prevalence of toxoplasmosis in pregnant women and the associated risk factors is the first step in defining policy for the prevention of congenital toxoplasmosis in a given population. An epidemiological study was conducted during prenatal consultations at the CHU-MEL of Cotonou (Benin) between September 2018 and April 2021 and recruited 549 pregnant women to determine the seroprevalence and potential factors associated with Toxoplasma gondii infection. Toxoplasma gondii IgG/IgM antibodies were detected using an enzyme-linked fluorescence assay (ELFA) technique, an IgG avidity test and an IgG/IgM comparative Western blot to diagnose the maternal toxoplasmosis serological status, the possibility of an infection acquired during pregnancy and congenital infection, respectively. Concomitantly, the participants answered a questionnaire investigating potential risk factors. Toxoplasmosis seroprevalence was estimated at 44.4% (95% CI 40.3-48.6) and the factors significantly associated with T. gondii seropositivity were: Age over 30 years, multigravid women and contact with cats. The possibility of an infection acquired during the periconceptional period or the first trimester of pregnancy concerned six women [1.1% (95% CI 0.5-2.0)]. However, due to the low rate of serological controls in seronegative women, a significant proportion of women first tested during the 3rd trimester of pregnancy, and an insufficient sample size, the incidence of primary infection during pregnancy could not be determined. No cases of congenital transmission occurred in the newborns from the suspected cases of primary infection. © A. Mercier et al., published by EDP Sciences, 2023.
Authors & Co-Authors
Mercier, Aurélien
France, Limoges
Université de Limoges
France, Limoges
Chu de Limoges
Amagbégnon, Richard
Benin, Cotonou
Service D'anesthésie-réanimation du Centre Hospitalier Universitaire de la Mère et de L´enfant-lagune
Benin, Abomey-calavi
Clinical Research Institute of Benin Ircb
Dechavanne, Célia
France, Marseille
Ird Institut de Recherche Pour le Developpement
Dambrun, Magalie
France, Marseille
Ird Institut de Recherche Pour le Developpement
Migot-Nabias, Florence
France, Marseille
Ird Institut de Recherche Pour le Developpement
Hamidović, Azra
France, Limoges
Université de Limoges
Fievét, Nadine
France, Marseille
Ird Institut de Recherche Pour le Developpement
Tonato-Bagnan, Angéline
Benin, Cotonou
Service D'anesthésie-réanimation du Centre Hospitalier Universitaire de la Mère et de L´enfant-lagune
Benin, Cotonou
University of Abomey-calavi
Ogouyèmi-Hounto, Aurore
Benin, Abomey-calavi
Clinical Research Institute of Benin Ircb
Benin, Cotonou
University of Abomey-calavi
Benin, Cotonou
National University Hospital Hubert Koutoukou Maga Cnhu-hkm
Alao, Maroufou Jules
Benin, Cotonou
Service D'anesthésie-réanimation du Centre Hospitalier Universitaire de la Mère et de L´enfant-lagune
Benin, Cotonou
University of Abomey-calavi
Dardé, Marie Laure
France, Limoges
Université de Limoges
France, Limoges
Chu de Limoges
Kindé-Gazard, Dorothée Akoko
Benin, Abomey-calavi
Clinical Research Institute of Benin Ircb
Benin, Cotonou
University of Abomey-calavi
Benin, Cotonou
National University Hospital Hubert Koutoukou Maga Cnhu-hkm
Statistics
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1051/parasite/2023040
ISSN:
1252607X
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Benin
Participants Gender
Female