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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Middle east respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia
mBio, Volume 5, No. 2, Article e00884-14, Year 2014
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Description
The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic and temporal survey of camels in the Kingdom of Saudi Arabia that MERS coronaviruses have been circulating in camels since at least 1992, are distributed countrywide, and can be phylogenetically classified into clades that correlate with outbreaks of the disease among humans. We found no evidence of infection in domestic sheep or domestic goats. © 2014 Alagaili et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3940034/bin/mbo001141764st1.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3940034/bin/mbo001141764st2.docx
Authors & Co-Authors
Alagaili, N. A.
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
Saudi Wildlife Authority
Briese, Thomas C.
United States, New York
Mailman School of Public Health
Mishra, Nischay
United States, New York
Mailman School of Public Health
Kapoor, Vishal
United States, New York
Mailman School of Public Health
Sameroff, Stephen C.
United States, New York
Mailman School of Public Health
de Wit, Emmie
United States, Bethesda
National Institutes of Health Nih
Munster, Vincent J.
United States, Bethesda
National Institutes of Health Nih
Hensley, Lisa E.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Zalmout, Iyad S.A.
Saudi Arabia, Riyadh
College of Sciences
Kapoor, Amit
United States, New York
Mailman School of Public Health
Epstein, Jonathan Harris
United States, New York
Ecohealth Alliance
Karesh, William B.
United States, New York
Ecohealth Alliance
Daszak, Peter
United States, New York
Ecohealth Alliance
Mohammed, Osama Badri
Saudi Arabia, Riyadh
College of Sciences
Lipkin, W. Ian
United States, New York
Mailman School of Public Health
Statistics
Citations: 416
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1128/mBio.00884-14
ISSN:
21612129
e-ISSN:
21507511
Research Areas
Covid
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative