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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of Liv-52 on carbon tetrachloride-induced changes in hepatic microsomal drug-metabolizing enzymes of the rat
Toxicology Letters, Volume 14, No. 3-4, Year 1982
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Description
The effects of the hepatotonic Liv-52 on carbon tetrachloride (CCl4) -induced changes in the activities of the microsomal enzymes, aniline hydroxylase, p-aminopyrine N-demethylase and aryl hydrocarbon hydroxylase (AHH), have been investigated. Treatment with Liv-52 (before or after CCl4 administration) markedly decreased, the CCl4-mediated reduction in aniline hydrochloride and p-aminopyrine N-demethylase activities, although the decrease in AHH activity could not be prevented. Kinetic studies showed that the effect of Liv-52 was not due to an alteration in the Km values of the enzymes. The possible mechanism by which Liv-52 moderated the CCl4-induced changes in the microsomal drug- metabolizing enzymes is discussed. © 1982.
Authors & Co-Authors
Thabrew, Myrtle Ira
Nigeria, Ibadan
University of Ibadan
Emerole, Godwin O.
Nigeria, Ibadan
University of Ibadan
Subbarao, V. V.
Nigeria, Ibadan
University of Ibadan
Statistics
Citations: 13
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/0378-4274(82)90049-2
ISSN:
03784274
Research Areas
Environmental