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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: Utility for detection of diverse HIV-1 subtypes
Journal of Acquired Immune Deficiency Syndromes, Volume 43, No. 3, Year 2006
Notification
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Description
Because increasing numbers of HIV vaccine candidates are being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Most of the currently tested vaccines contain multiple viral components. As a result, many vaccine recipients give positive results in FDA-licensed HIV serodetection tests. We have identified conserved sequences in Env-gp41 and Gag-p6, which are recognized soon after infection but are not included in most HIV vaccine candidates. A new HIV serodetection assay, the HIV-SELECTEST, was established that distinguishes between vaccine-induced antibodies and seroconversion due to true HIV infections. It is important to make this assay globally relevant, because many clinical trials are conducted around the world where most HIV infections are due to non-B subtype HIV-1. Therefore, the current study examined the reactivity of plasma samples from >3000 infections with diverse HIV subtypes worldwide. The HIV-SELECTEST performed at >99% specificity and sensitivity. Both recent and established infections with clades A, B, C, D, E, F, G, J, and CRFs were detected. Antibodies elicited by other vaccinations or infections endemic to the clinical trial sites did not react in this assay. Therefore, HIV-SELECTEST could be an important differential diagnostic tool for HIV vaccine trials, blood banks, and population screening worldwide. © 2006 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Khurana, Surender
United States, Silver Spring
Food and Drug Administration
Needham, James
United States, Silver Spring
Food and Drug Administration
Park, Susan
United States, Silver Spring
Food and Drug Administration
Mathieson, Bonnie J.
United States, Bethesda
National Institutes of Health Nih
Busch, Michael P.
United States, San Francisco
Vitalant Research Institute
Nemo, George J.
United States, Bethesda
National Heart, Lung, and Blood Institute Nhlbi
Nyambi, Phillipe N.
United States, New York
New York University
Zolla Pazner, Susan B.
United States, New York
New York University
Laal, Suman
United States, New York
New York University
Mulenga, Joseph
Zambia, Lusaka
Zambia-uab Hiv Research Project
Zambia, Lusaka
Zambia Blood Transfusion Service
Chomba, Elwyn Nachanya
Zambia, Lusaka
Zambia-uab Hiv Research Project
Hunter, Eric
United States, Atlanta
Emory University
Allen, Susan A.
United States, Atlanta
Emory University
McIntyre, James Alasdair
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Hewlett, Indira K.
United States, Silver Spring
Food and Drug Administration
Lee, Sherwin F.
United States, Silver Spring
Food and Drug Administration
Tang, Shixing
United States, Silver Spring
Food and Drug Administration
Cowan, Elliot P.
United States, Silver Spring
Food and Drug Administration
Beyrer, Chris C.
United States, Baltimore
Johns Hopkins University
Altfeld, Marcus A.
United States, Charlestown
Ma Gen.hosp.
Yu, Xu G.
United States, Charlestown
Ma Gen.hosp.
Tounkara, Anatole
Mali, Bamako
University of Bamako
Koita, Ousmane A.
Mali, Bamako
University of Bamako
Kamali, Anatoli
Uganda
Medical Research Council Mrc-masaka
Nguyen, Nga Yen
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Graham, Barney S.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Todd, Deborah S.
United States, Rockville
Westat, Inc.
Mugenyi, Peter
Uganda, Gulu
Joint Clinical Research Centre
Anzala, Aggrey Omu
Kenya, Nairobi
University of Nairobi
Sanders, Eduard Joachim
Kenya, Kilifi
Center for Geographic Medicine Cost Research
Ketter, Nzeera
United States, New York
International Aids Vaccine Initiative
Fast, Patricia E.
United States, New York
International Aids Vaccine Initiative
Golding, Hana A.
United States, Silver Spring
Food and Drug Administration
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Statistics
Citations: 33
Authors: 33
Affiliations: 20
Identifiers
Doi:
10.1097/01.qai.0000242465.50947.5f
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study