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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent
PLoS Pathogens, Volume 7, No. 2, Article e1001283, Year 2011
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Description
From which host did the most malignant human malaria come: birds, primates, or rodents? When did the transfer occur? Over the last half century, these have been some of the questions up for debate about the origin of Plasmodium falciparum, the most common and deadliest human malaria parasite, which is responsible for at least one million deaths every year. Recent findings bring elements in favor of a transfer from great apes, but are these evidences really solid? What are the grey areas that remain to be clarified? Here, we examine in depth these new elements and discuss how they modify our perception of the origin and evolution of P. falciparum. We also discuss the perspectives these new discoveries open. © 2011 Prugnolle et al.
Authors & Co-Authors
Prugnolle, Franck
France, Montpellier
Ird Centre de Montpellier
Durand, Patrick
France, Montpellier
Ird Centre de Montpellier
Ollomo, Benjamin
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Duval, Linda
France, Montpellier
Ird Centre de Montpellier
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Ariey, Frédéric
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Arnathau, Céline
France, Montpellier
Ird Centre de Montpellier
Gonzalez, J. P.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Leroy, Éric Maurice
France, Montpellier
Ird Centre de Montpellier
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Renaud, François N.R.
France, Montpellier
Ird Centre de Montpellier
Statistics
Citations: 107
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1371/journal.ppat.1001283
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Cancer
Infectious Diseases