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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Malaria co-infection in children influences antibody response to schistosome antigens and inflammatory markers associated with morbidity
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 97, No. 3, Year 2003
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Description
The epidemiological coexistence of schistosomiasis and malaria is frequently observed in developing countries. Co-infection with malaria in children could influence the development of acquired immunity associated with the resistance or the pathology of schistosomiasis. In the present study, performed during May to June 1996 in Senegal, the humoral immune response to Schistosoma haematobium 28 kDa glutathione S-transferase (Sh28GST) vaccinal antigen and to soluble egg antigens (SEA) has been evaluated in individuals infected by S. haematobium. Specific immunoglobulin G3 (IgG3) and IgE responses were significantly higher in co-infected children with Plasmodium falciparum compared with children infected with S. haematobium only. In addition, circulating levels of interferon-γ (IFN-γ), interleukin-10 (IL-10), and soluble tumor necrosis factor receptor II (sTNF-RII), 3 parameters associated with schistosomiasis morbidity, were significantly increased in co-infected children. Taken together, this study indicated that malaria co-infection can both influence the acquired specific immune response to schistosome antigens and unbalance the regulation of inflammatory factors closely involved in schistosomiasis pathology. © 2003 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Remoué, Franck J.
France, Lille
Institut Pasteur de Lille
France, Montpellier
Ird Centre de Montpellier
Diallo, Tamsir O.
France, Lille
Institut Pasteur de Lille
Angéli, Véronique
France, Lille
Institut Pasteur de Lille
Hervé, Maxime
France, Lille
Institut Pasteur de Lille
de Clercq, Dick
Senegal, Saint Louis
Programme Espoir
Schacht, Anne Marie
France, Lille
Institut Pasteur de Lille
Charrier, Nicole
Senegal, Saint Louis
Programme Espoir
Capron, Monique
France, Lille
Institut Pasteur de Lille
Vercruysse, Jozef
Belgium, Ghent
Universiteit Gent
Ly, Abdoulaye
Senegal, Saint Louis
Programme Espoir
Caprón, André R.
France, Lille
Institut Pasteur de Lille
Riveau, Gilles J.
France, Lille
Institut Pasteur de Lille
Statistics
Citations: 38
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/S0035-9203(03)90170-2
ISSN:
00359203
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Senegal