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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons
Journal of the American College of Cardiology, Volume 6, No. 6, Year 1985
Notification
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Description
The effects of 15 minute periods of coronary artery occlusion on plasma creatine kinase (CK) and CK-MB isoenzyme activity, regional myocardial function and subsequent myocardial necrosis were studied in six conscious baboons 2 to 3 weeks after recovery from instrumentation. Mid left anterior descending coronary artery occlusion induced complete loss of systolic wall thickening (ultrasound transit time technique) and decreases in epicardial (-93%) and endocardial (-96%) blood flows (microsphere technique). Reperfusion after 15 minutes resulted in complete recovery of regional function 24 hours later. Serial plasma enzyme activity revealed a significant increase in total CK from 71 ± 11 to 976 ± 158 U/liter and in CK-MB from levels that were too low to measure to 21.4 ± 2.9 U/liter. At autopsy, neither gross pathologic evidence (triphenyltetrazolium chloride staining technique) nor histologic evidence of myocardial necrosis was observed. Thus, in the conscious baboon short episodes of myocardial ischemia are associated with a significant appearance of CK and CK-MB in the blood in the absence of cellular necrosis. © 1985, American College of Cardiology Foundation. All rights reserved.
Authors & Co-Authors
Heyndrickx, Guy Robert
United States, Boston
Brigham and Women's Hospital
Amano, Jun
United States, Boston
Brigham and Women's Hospital
Kenna, Twila
United States, Boston
Brigham and Women's Hospital
Fallon, John T.
United States, Boston
Massachusetts General Hospital
Patrick, Thomas A.
United States, Boston
Brigham and Women's Hospital
Manders, W. Thomas
United States, Boston
Brigham and Women's Hospital
Rogers, Geoffrey G.
South Africa, Tygerberg
South African Medical Research Council
Rosendorff, Clive
South Africa, Tygerberg
South African Medical Research Council
Vatner, Stephen F.
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 110
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/S0735-1097(85)80216-3
ISSN:
07351097