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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
Electrospinning collagen/chitosan/poly(L-lactic acid-co-ε- caprolactone) to form a vascular graft: Mechanical and biological characterization
Journal of Biomedical Materials Research - Part A, Volume 101 A, No. 5, Year 2013
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Description
For blood vessel tissue engineering, an ideal vascular graft should possess excellent biocompatibility and mechanical properties. For this study, a elastic material of poly (L-lactic acid-co-ε-caprolactone) (P(LLA-CL)), collagen and chitosan blended scaffold at different ratios were fabricated by electrospinning. Upon fabrication, the scaffolds were evaluated to determine the tensile strength, burst pressure, and dynamic compliance. In addition, the contact angle and endothelial cell proliferation on the scaffolds were evaluated to demonstrate the structures potential to serve as a vascular prosthetic capable of in situ regeneration. The collagen/chitosan/P(LLA-CL) scaffold with the ratio of 20:5:75 reached the highest tensile strength with the value of 16.9 MPa, and it was elastic with strain at break values of ∼112%, elastic modulus of 10.3 MPa. The burst pressure strength of the scaffold was greater than 3365 mmHg and compliance value was 0.7%/100 mmHg. Endothelial cells proliferation was significantly increased on the blended scaffolds versus the P(LLA-CL). Meanwhile, the endothelial cells were more adherent based on the increase in the degree of cell spreading on the surface of collagen/chitosan/ P(LLA-CL) scaffolds. Such blended scaffold especially with the ratio of 20:5:75 thus has the potential for vascular graft applications. © 2012 Wiley Periodicals, Inc.
Authors & Co-Authors
Yin, Anlin
China, Shanghai
Donghua University
United States, Richmond
Virginia Commonwealth University
Zhang, Kuihua
China, Jiaxing
Jiaxing University
McClure, Michael J.
United States, Richmond
Virginia Commonwealth University
Huang, Chen
China, Shanghai
Donghua University
Wu, Jinglei
China, Shanghai
Donghua University
Fang, Jun
China, Shanghai
Donghua University
Mo, Xiumei
China, Shanghai
Donghua University
Bowlin, Gary L.
United States, Richmond
Virginia Commonwealth University
Al-Deyab, Salem Salem
Saudi Arabia, Riyadh
College of Sciences
El-Newehy, Mohamed Hassan
Saudi Arabia, Riyadh
College of Sciences
Egypt, Tanta
Faculty of Science
Statistics
Citations: 113
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1002/jbm.a.34434
ISSN:
15493296
e-ISSN:
15524965