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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Influenza A (H
1
N
1
) antiviral and cytotoxic agents from Ferula assa-foetida
Journal of Natural Products, Volume 72, No. 9, Year 2009
Notification
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Description
Two new sesquiterpene coumarins, designated 5′-acetoxy-8′- hydroxyumbelliprenin (1) and 10′R-acetoxy-11′-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl3-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1-3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6-13 showed greater potency against influenza A virus (H1N1) (IC50 0.26-0.86 μg/mL) than amantadine (IC50 0.92 μg/mL), and 11 exhibited the best potency (IC50 0.51, 2.6, and 3.4 μg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively. © 2009 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Lee, Chialin
Taiwan, Kaohsiung
Kaohsiung Medical University
Chiang, Lienchai
Taiwan, Kaohsiung
College of Medicine
Cheng, Lihung
Taiwan, Kaohsiung
Kaohsiung Medical University
Liaw, Chinchuang
Taiwan, Taichung
China Medical University
Abd El-Razek, Mohamed H.
Egypt, Giza
National Research Centre
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Wu, Yangchang
Taiwan, Kaohsiung
Kaohsiung Medical University
Statistics
Citations: 186
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1021/np900158f
ISSN:
01633864
Research Areas
Cancer