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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of anticonvulsive treatment on neuropsychological performance in children with BECTS
European Journal of Paediatric Neurology, Volume 20, No. 6, Year 2016
Notification
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Description
Introduction Benign epilepsy with centrotemporal spikes (BECTS) is a common epilepsy syndrome in childhood. Besides the occurrence of seizures, mild cognitive impairments and behavioral problems affecting language skills, spatial perception, memory, executive function, and academic achievement might be present. There is no international consensus about the decision whether or not to treat affected children. The influence of treatment on cognitive functions is debated. Methods Patients diagnosed with BECTS were assessed in short term auditory memory, long-term verbal memory, intelligence and behavior using the “number recall” test from the Kaufman assessment battery for children, the “verbal learning memory test”, the “culture free intelligence test” and the “child behavior checklist” prior to a randomized controlled antiepileptic therapy and after a treatment period of 6 months with either sulthiame or levetiracetam. Results 43 of 44 randomized patients were analyzed. One patient had to be excluded due to protocol violation. Patients who completed the study showed a non-significant improvement in parent-reported behavioral problems under therapy. Cognitive skills were not affected. Conclusion The present data suggest that antiepileptic drug treatment of children with BECTS with either sulthiame or levetiracetam does not affect cognitive performance. Behavior improved in a subset of patients though not reaching statistical significance. © 2016 European Paediatric Neurology Society
Authors & Co-Authors
Tacke, Moritz
Germany, Munich
Ludwig-maximilians-universität München
Bast, Thomas
Unknown Affiliation
Borggraefe, Ingo
Germany, Munich
Ludwig-maximilians-universität München
Baumeister, Friedrich A.M.
Germany, Rosenheim
Children's Hospital
Bode, Harald
Germany, Ulm
Universitätsklinikum Ulm
Wagner, Ryan G.
Unknown Affiliation
Brandl, Ulrich
Germany, Jena
Universitätsklinikum Jena Und Medizinische Fakultät
Brockmann, Knut
Germany, Gottingen
Universitätsmedizin Göttingen
Klepper, Jörg
Germany, Aschaffenburg
Klinikum Aschaffenburg
Kluger, Gerhard Josef
Unknown Affiliation
Korinthenberg, Rudolf
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Kurlemann, Gerhard
Germany, Munster
Universitätsklinikum Münster
Rating, Dietz
Germany, Heidelberg
Universitätsklinikum Heidelberg
Schara, Ulrike
Germany, Duisburg
Universität Duisburg-essen
Stephani, Ulrich
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Mühle, Hiltrud
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Waltz, Stephan
Unknown Affiliation
Wolff, Markus
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Polster, Tilman
Germany, Bielefeld
Epilepsiezentrum Bethel
Statistics
Citations: 21
Authors: 19
Affiliations: 24
Identifiers
Doi:
10.1016/j.ejpn.2016.07.015
ISSN:
10903798
Research Areas
Cancer
Health System And Policy
Maternal And Child Health