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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Characterization of neutrophil subsets in healthy human pregnancies
PLoS ONE, Volume 9, No. 2, Article e85696, Year 2014
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Description
We have previously shown that in successful pregnancies increased arginase activity is a mechanism that contributes to the suppression of the maternal immune system. We identified the main type of arginase-expressing cells as a population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells and in term placentae. In the present study, we analyzed the phenotype of LDGs and compared it to the phenotype of normal density granulocytes (NDGs) in maternal peripheral blood, placental biopsies and cord blood. Our data reveal that only LDGs but no NDGs could be detected in placental biopsies. Phenotypically, NDGs and LDGs from both maternal and cord blood expressed different levels of maturation, activation and degranulation markers. NDGs from the maternal and cord blood were phenotypically similar, while maternal, cord and placental LDGs showed different expression levels of CD66b. LDGs present in cord blood expressed higher levels of arginase compared to maternal and placental LDGs. In summary, our results show that in maternal and cord blood, two phenotypically different populations of neutrophils can be identified, whereas in term placentae, only activated neutrophils are present. © 2014 Ssemaganda et al.
Authors & Co-Authors
Ssemaganda, Aloysius
Uganda, Entebbe
Uganda Virus Research Institute
Kindinger, Lindsay
United Kingdom, London
St Mary's Hospital
Bergin, Philip J.
United States, New York
International Aids Vaccine Initiative
Nielsen, Leslie Elizabeth
Uganda, Entebbe
Uganda Virus Research Institute
Mpendo, Juliet
Uganda, Entebbe
Uganda Virus Research Institute
Ssetaala, Ali
Uganda, Entebbe
Uganda Virus Research Institute
Kiwanuka, Noah
Uganda, Entebbe
Uganda Virus Research Institute
Uganda, Kampala
Makerere University
Munder, Markus
Germany, Mainz
Universitätsmedizin Mainz
Teoh, Tiong Ghee
United Kingdom, London
St Mary's Hospital
Kropf, Pascale
United Kingdom, London
Imperial College London
Müller, Ingrid
United Kingdom, London
Imperial College London
Statistics
Citations: 69
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0085696
e-ISSN:
19326203
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study