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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The effect of indoor residual spraying on malaria and anemia in a high-transmission area of Northern Uganda
American Journal of Tropical Medicine and Hygiene, Volume 88, No. 5, Year 2013
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Description
Indoor residual spraying (IRS) with insecticide is now recommended for malaria control in high-transmission settings. However, concerns about insecticide resistance have increased. We conducted a cross-sectional household survey in high-transmission northern Uganda in two districts previously sprayed with pyrethroids before documentation of pyrethroid resistance and at least one round of carbamates and in one contiguous district that was not sprayed. Parasitemia prevalence among children < 5 years of age was lower in the two IRS districts compared with the non-sprayed district: 37.0% and 16.7% versus 49.8%, P < 0.001. Anemia prevalence was also significantly lower in the two IRS districts: 38.8% and 36.8% versus 53.0%, P < 0.001. Multivariable Poisson regression models indicated that a child living in a sprayed district had a 46% and 32% lower risk of parasitemia and anemia, respectively, than a child in a non-sprayed district (P < 0.001). Carefully managed IRS can significantly reduce malaria burden in high-transmission settings. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Steinhardt, Laura C.
United States, Atlanta
Centers for Disease Control and Prevention
Yeka, Adoke
Uganda, Kampala
Uganda Malaria Surveillance Project
Nasr, Sussann
United States, Atlanta
Centers for Disease Control and Prevention
Wiegand, Ryan E.
United States, Atlanta
Centers for Disease Control and Prevention
Rubahika, Denis
Uganda
Uganda National Malaria Control Programme
Sserwanga, Asadu
Uganda, Kampala
Uganda Malaria Surveillance Project
Wanzira, Humphrey
Uganda, Kampala
Uganda Malaria Surveillance Project
Lavoy, Geoff
Uganda, Kampala
Uganda Malaria Surveillance Project
Kamya, Moses Robert K.
Uganda, Kampala
Uganda Malaria Surveillance Project
Dorsey, Grant M.
United States, San Francisco
University of California, San Francisco
Filler, Scott J.
Switzerland, Geneva
Fonds Mondial de Lutte Contre le Sida, la Tuberculose et le Paludisme
Statistics
Citations: 60
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.12-0747
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Uganda