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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa
Inflammopharmacology, Volume 19, No. 1, Year 2011
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Description
The in vitro hepatoprotective effect of the methanolic extract from Ficus gnaphalocarpa (Miq.) Steud. ex A. Rich (Moraceae) on the CCl4-induced liver cell damage as well as the possible antioxidant mechanisms involved in this protective effect, were investigated. The phytochemical investigation of this methanolic extract led to the isolation of six compounds identified as: betulinic acid (1); 3-methoxyquercetin (2); catechin (3); epicatechin (4); quercetin (5); and quercitrin (6). The hepatoprotective activity of these compounds was tested in vitro against CCl4-induced damage in rat hepatoma cells. In addition, radical-scavenging activity, β-carotene- linoleic acid model system, ferric-reducing antioxidant parameter and microsomal lipid peroxidation assays were used to measure antioxidant activity of crude extract and isolated compounds. Silymarin and trolox were used as standard references and, respectively, exhibited significant hepatoprotective and antioxidant activities. (5), (6) and (2) showed significant antioxidant and hepatoprotective activities as indicated by their ability to prevent liver cell death and lactate dehydrogenase leakage during CCl4 intoxication. These results suggest that the protective effects of crude extract of F. gnaphalocarpa against the CCl4-induced hepatotoxicity possibly involve the antioxidant effect of these compounds. © 2010 Springer Basel AG.
Authors & Co-Authors
Donfack, Jean Hubert
Cameroon, Yaounde
Université de Yaoundé I
Dawé, Amadou
Cameroon, Yaounde
Université de Yaoundé I
Florence, Ngueguim Tsofack
Cameroon, Yaounde
Université de Yaoundé I
Gilbert, Kapche D.W.F.
Cameroon, Yaounde
Université de Yaoundé I
Angele, Tchana N.
Cameroon, Yaounde
Université de Yaoundé I
Buonocore, Daniela
Italy, Pavia
Università Degli Studi Di Pavia
Finzi, Paola Vita
Italy, Pavia
Università Degli Studi Di Pavia
Vidari, Giovanni
Italy, Pavia
Università Degli Studi Di Pavia
Bonaventure, Ngadjui Tchaleu
Cameroon, Yaounde
Université de Yaoundé I
Marzatico, Fulvio
Italy, Pavia
Università Degli Studi Di Pavia
Paul, Moundipa Fewou
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 21
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1007/s10787-010-0070-4
ISSN:
09254692
e-ISSN:
15685608