Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Local intracoronary eptifibatide versus mechanical aspiration in patients with acute ST-elevation myocardial infarction
International Journal of Vascular Medicine, Volume 2014, Article 294065, Year 2014
Notification
URL copied to clipboard!
Description
Objectives. We compared local delivery of intracoronary eptifibatide via perfusion catheter to thrombus aspiration in primary PCI. Background. Perfusion catheter increases local concentration of the drugs at the culprit site and prolongs their residency time. Methods. 75 patients with acute STEMI were randomized to three groups: 25 received local intracoronary eptifibatide and verapamil via perfusion catheter; 25 patients were managed by Diver CE thrombectomy device and 25 patients by primary PCI without thrombus aspiration. Primary end point was assessment of postprocedural TIMI flow, MPG, and corrected TIMI frame count (cTFC) in the culprit vessel. Results. Perfusion catheter was superior to thrombus aspiration and conventional PCI as regards MBG (68% versus 36% in Diver CE and 20% in the control arm; P value = 0.002), with shorter cTFC rates than thrombectomy and control groups (20.76±4.44 versus 26.68±8.40 and 28.16±5.96, resp.; P=0.001). TIMI flow was not different between the 3 groups. Eptifibatide led to less time to peak CK (13.12 hours versus 16.5 and 19.5 hours, respectively, P value = 0.001). Conclusion. Local intracoronary eptifibatide by perfusion catheter reduces thrombus burden with better results in microvascular perfusion assessed by cTFC and MBG compared to aspiration device or conventional PCI. © 2014 Mohamed A. Hamza et al.
Authors & Co-Authors
Hamza, Mohamed Atef
Egypt, Cairo
Ain Shams University
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Galal, Ayman
Egypt, Cairo
Ain Shams University
Suweilam, Salwa
Egypt, Cairo
Ain Shams University
Ismail, Mohamed
Egypt, Cairo
Ain Shams University
Statistics
Citations: 12
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1155/2014/294065
ISSN:
20902824
e-ISSN:
20902832