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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Surface Properties, Connective Tissue Protein Binding and Shiga-like Toxin Production of Escherichia coli Isolated from Patients with Ulcerative Colitis
Zentralblatt fur Bakteriologie, Volume 276, No. 2, Year 1992
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Description
Escherichia coli strains isolated from intestinal biopsies of patients with ulcerative colitis (n 146), Crohn's disease and colonic polyposis (n 41) were analysed for binding of collagen I, collagen IV, fibronectin and laminin. Strains expressed varying degrees of binding of one or more of the four connective tissue proteins. Only 32 strains did not express binding of any of the proteins. The strains expressed low or moderate cell surface hydrophobicity. There was no correlation between protein binding and expression of cell surface hydrophobicity. E. coli isolated from inflamed rectal mucosa were slightly less negatively charged than strains isolated from healthy intestinal mucosa. Shiga-like toxins I and II were detected in 32 strains from 28 patients. Of these, 5 strains had been isolated from normal or healed tissue. In patients with inflammatory bowel disease, connective tissue proteins are exposed in intestinal ulcerations. Strains expressing binding of one or several of these proteins may have a selective advantage to colonize these lesions. © 1992, Gustav Fischer Verlag, Stuttgart · New York. All rights reserved.
Authors & Co-Authors
Olusanya, O.
Sweden, Lund
Lunds Universitet
Nigeria, Ago-iwoye
Olabisi Onabanjo University
Steinrück, Hartmut
Sweden, Lund
Lunds Universitet
Germany, Berlin
Robert Koch Institute
Aleljung, P.
Sweden, Lund
Lunds Universitet
Ascencio, Felipe
Sweden, Lund
Lunds Universitet
Mexico, La Paz
Centro de Investigaciones Biologicas Del Noroeste
Curman, B.
Sweden, Orebro
Universitssjukhuset Örebro
Järnerot, G.
Sweden, Orebro
Universitssjukhuset Örebro
Wadström, Torkel M.
Sweden, Lund
Lunds Universitet
Ljungh, Åsa
Sweden, Lund
Lunds Universitet
Statistics
Citations: 9
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/S0934-8840(11)80012-5