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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Colistin as a salvage therapy for nosocomial infections caused by multidrug-resistant bacteria in the ICU
International Journal of Antimicrobial Agents, Volume 28, No. 4, Year 2006
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Description
The objective of this study was to determine the efficacy of systemic colistin therapy in the treatment of nosocomial infections caused by multidrug-resistant Acinetobacter baumannii or Pseudomonas aeruginosa and to study related adverse events. We prospectively studied 78 infections caused by multidrug-resistant A. baumannii or P. aeruginosa that were treated with colistin. The sites of infection were pulmonary infection (78.2%), urinary tract infection (7.7%), primary bloodstream infection (11.5%) and meningitis (2.6%). The mean daily dose of colistin was 5.5 ± 1.1 MU/day (range 2-9 MU/day) and the mean duration of colistin therapy was 9.3 ± 3.8 days (range 5-21 days). A favourable clinical response to colistin occurred in 60 cases (76.9%). Renal failure occurred in only seven cases. We conclude that colistin can be a safe and effective salvage therapeutic option for nosocomial infections caused by multidrug-resistant A. baumannii or P. aeruginosa. © 2006 Elsevier B.V. and the International Society of Chemotherapy.
Authors & Co-Authors
Kallel, Hatem
Tunisia, Sfax
Chu Habib Bourguiba
Bahloul, Mabrouk
Tunisia, Sfax
Chu Habib Bourguiba
Hergafi, Leila
Tunisia, Sfax
Chu Habib Bourguiba
Akrout, Malek
Tunisia, Sfax
Chu Habib Bourguiba
Ketata, Wajdi
Tunisia, Sfax
Chu Habib Bourguiba
Chelly, Hédi E.
Tunisia, Sfax
Chu Habib Bourguiba
Hamida, Chokri Ben
Tunisia, Sfax
Chu Habib Bourguiba
Rekik, Noureddine
Tunisia, Sfax
Chu Habib Bourguiba
Hammami, Adenène
Tunisia, Sfax
Chu Habib Bourguiba
Bouaziz, Mounir
Tunisia, Sfax
Chu Habib Bourguiba
Statistics
Citations: 106
Authors: 10
Affiliations: 1
Identifiers
Doi:
10.1016/j.ijantimicag.2006.07.008
ISSN:
09248579
Research Areas
Cancer