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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma
Biology of Blood and Marrow Transplantation, Volume 20, No. 7, Year 2014
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Description
There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-HCT; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-HCTs were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8% (95% confidence interval [CI], 4% to 14%), 5-year progression-free survival of 35% (95% CI, 26% to 45%), and 5-year overall survival of 50% (95% CI, 40% to 59%). In contrast, allo-HCT was associated with a 1-year NRM of 41% (95% CI, 23% to 58%), 5-year progression-free survival of 18% (95% CI, 6% to 35%), and 5-year overall survival of 22% (95% CI, 8% to 41%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality. © 2014 American Society for Blood and Marrow Transplantation.
Authors & Co-Authors
Wirk, Baldeep
Unknown Affiliation
Fenske, Timothy S.
Unknown Affiliation
Hamadani, Mehdi
Unknown Affiliation
Zhang, Meijie
Unknown Affiliation
Hu, Zhen Huan
Unknown Affiliation
Akpek, Görgun
Unknown Affiliation
Aljurf, Mahmoud Deeb
Unknown Affiliation
Armand, Philipe
Unknown Affiliation
Ayala, Ernesto
Unknown Affiliation
Bachanova, V.
Unknown Affiliation
Bolwell, Brian
Unknown Affiliation
Cairo, Mitchell S.
Unknown Affiliation
Cashen, Amanda
Unknown Affiliation
Chen, Yibin A.
Unknown Affiliation
Costa, Luciano José Megale
Unknown Affiliation
Farhan, Shatha
Unknown Affiliation
Freytes, César O.
Unknown Affiliation
Gajewski, James
Unknown Affiliation
Gibson, John
Unknown Affiliation
Hale, Gregory A.
Unknown Affiliation
Holmberg, Leona A.
Unknown Affiliation
Hsu, Jack W.
Unknown Affiliation
Inwards, David
Unknown Affiliation
Kamble, Rammurti T.
Unknown Affiliation
Maharaj, Dipnarine
Unknown Affiliation
Maziarz, Richard T.
Unknown Affiliation
Munker, Reinhold
Unknown Affiliation
Nath, Rajneesh
Unknown Affiliation
Reddy, Nishitha M.
Unknown Affiliation
Reeder, Craig B.
Unknown Affiliation
Rizzieri, David
Unknown Affiliation
Sauter, Craig S.
Unknown Affiliation
Savani, Bipin N.
Unknown Affiliation
Schouten, Harry C.
Unknown Affiliation
Sureda Balari, Anna Maria
Unknown Affiliation
Vose, Julie
Unknown Affiliation
Waller, Edmund K.
Unknown Affiliation
Wiernik, Peter H.
Unknown Affiliation
Gale, Robert Peter
Unknown Affiliation
Burns, Linda J.
Unknown Affiliation
Saber, Wael
Unknown Affiliation
Statistics
Citations: 41
Authors: 41
Affiliations: 38
Identifiers
Doi:
10.1016/j.bbmt.2014.03.014
ISSN:
10838791
e-ISSN:
15236536