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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Insecticide resistance in the sand fly, Phlebotomus papatasi from Khartoum State, Sudan
Parasites and Vectors, Volume 5, No. 1, Article 46, Year 2012
Notification
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Description
Background: Phlebotomus papatasi the vector of cutaneous leishmaniasis (CL) is the most widely spread sand fly in Sudan. No data has previously been collected on insecticide susceptibility and/or resistance of this vector, and a first study to establish a baseline data is reported here. Methods. Sand flies were collected from Surogia village, (Khartoum State), Rahad Game Reserve (eastern Sudan) and White Nile area (Central Sudan) using light traps. Sand flies were reared in the Tropical Medicine Research Institute laboratory. The insecticide susceptibility status of first progeny (F1) of P. papatasi of each population was tested using WHO insecticide kits. Also, P. papatasi specimens from Surogia village and Rahad Game Reserve were assayed for activities of enzyme systems involved in insecticide resistance (acetylcholinesterase (AChE), non-specific carboxylesterases (EST), glutathione-S-transferases (GSTs) and cytochrome p450 monooxygenases (Cyt p450). Results: Populations of P. papatasi from White Nile and Rahad Game Reserve were sensitive to dichlorodiphenyltrichloroethane (DDT), permethrin, malathion, and propoxur. However, the P. papatasi population from Surogia village was sensitive to DDT and permethrin but highly resistant to malathion and propoxur. Furthermore, P. papatasi of Surogia village had significantly higher insecticide detoxification enzyme activity than of those of Rahad Game Reserve. The sand fly population in Surogia displayed high AChE activity and only three specimens had elevated levels for EST and GST. Conclusions: The study provided evidence for malathion and propoxur resistance in the sand fly population of Surogia village, which probably resulted from anti-malarial control activities carried out in the area during the past 50 years. © 2012 Hassan et al.
Authors & Co-Authors
Hassan, Mo'Awia Mukhtar
Sudan, Khartoum
Tropical Medicine Research Institute Sudan
Widaa, S. O.
Sudan, Khartoum
Tropical Medicine Research Institute Sudan
Sudan, Wad Medani
University of Gezira
Osman, Omran Fadol
Sudan, Khartoum
Tropical Medicine Research Institute Sudan
Numiary, Mona Siddig Mohammed
Sudan, Khartoum
Tropical Medicine Research Institute Sudan
Ibrahim, M. A.
Sudan, Khartoum
Tropical Medicine Research Institute Sudan
Abushama, Hind M.
Sudan, Khartoum
Khartoum University
Statistics
Citations: 61
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1186/1756-3305-5-46
e-ISSN:
17563305
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Sudan