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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Studies on the Antiinflammatory, Antipyretic and Analgesic Activities of Santonin
The Japanese Journal of Pharmacology, Volume 64, No. 3, Year 1994
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Description
Santonin, a sesquiterpene lactone, commonly found in the plants of the family Compositae was found to show significant antiinflammatory activity on acute inflammatory processes. The activity profile of santonin closely resembled that of a standard non-steroidal antiinflammatory drug, diclofenac sodium. It also showed a significant inhibitory effect on granuloma formation; however, this effect of santonin was less pronounced as compared to diclofenac sodium. Santonin caused a significant antipyretic effect in mice, which was found to be independent of the route of administration of the drug. It also increased the hot plate reaction time of treated mice, similar to morphine. © 1994, The Japanese Pharmacological Society. All rights reserved.
Authors & Co-Authors
Al-Harbi, Mohammed Matar
Saudi Arabia, Riyadh
College of Pharmacy
Raza, Muhammad
Saudi Arabia, Riyadh
College of Pharmacy
Qureshi, Shoeb
Saudi Arabia, Riyadh
King Saud University
Ahmed, Mohammad M.
Saudi Arabia, Riyadh
King Saud University
Miana, Ghulam Abbas
Pakistan, Dera Ismail Khan
Gomal University
Shah, Arif Hussain
Pakistan, Dera Ismail Khan
Gomal University
Statistics
Citations: 36
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1254/jjp.64.135
ISSN:
00215198