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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Central African Republic is part of the West-African hepatitis B virus genotype E crescent
Journal of Clinical Virology, Volume 40, No. 1, Year 2007
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Description
Background: Recent studies have shown that Hepatitis B virus (HBV) genotype E predominates in a vast crescent in West-Africa spanning from Senegal to Angola. Objectives: To determine whether HBV strains in the Central African Republic (CAR) belong predominately to the homogeneous West-African genotype E or whether they are more closely related to genotypes found in East Africa. Study design: Serum samples were randomly collected from 196 patients admitted with symptoms of acute or chronic hepatitis to the Central Hospital in Bangui. Thirty complete and 36 partial sequences of HBV strains were obtained. Results: Ninety-four percent (62/66) of the strains belonged to genotype E, while genotype A1, most closely related to a strain from Tanzania and genotype D were detected in only one and three samples, respectively. One strain presented a recombination between the S and X gene of a genotype E precursor and a partial PreC/C gene of a genotype D precursor. Conclusions: Genotype E is predominant in CAR with little overlap with genotypes from Eastern Africa, extending the West-African HBV genotype E crescent further to the East. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Bekondi, Claudine
Central African Republic, Bangui
Institut Pasteur de Bangui
France, Vandoeouvre-les-nancy
Laboratoire Lorrain de Chimie Moléculaire
Olinger, Christophe M.
Luxembourg
Who Collaborative Centre for Measles
Boua, Nathalie
Central African Republic
Hôpital de L'amitié
Talarmin, Antoine
Central African Republic, Bangui
Institut Pasteur de Bangui
Muller, Claude P.
Luxembourg
Who Collaborative Centre for Measles
Le Faou, Alain E.
Central African Republic, Bangui
Institut Pasteur de Bangui
France, Vandoeouvre-les-nancy
Laboratoire Lorrain de Chimie Moléculaire
Venard, Véronique
France, Vandoeouvre-les-nancy
Laboratoire Lorrain de Chimie Moléculaire
Statistics
Citations: 68
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.jcv.2007.05.009
ISSN:
13866532
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Locations
Multi-countries
Angola
Central African Republic
Senegal
Tanzania